Ki Summary

Reaction Details

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Target

REST corepressor 1

Ligand

BDBM50586372

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2168533 (CHEMBL5053592)

640±n/a nM

Citation

Kitagawa, H; Kikuchi, M; Sato, S; Watanabe, H; Umezawa, N; Kato, M; Hisamatsu, Y; Umehara, T; Higuchi, T Structure-Based Identification of Potent Lysine-Specific Demethylase 1 Inhibitor Peptides and Temporary Cyclization to Enhance Proteolytic Stability and Cell Growth-Inhibitory Activity. J Med Chem64:3707-3719 (2021) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

REST corepressor 1

Name:

REST corepressor 1

Synonyms:

Type:

PROTEIN

Mol. Mass.:

53329.34

Organism:

Homo sapiens (Human)

Description:

ChEMBL_108118

Residue:

485

Sequence:

MPAMVEKGPEVSGKRRGRNNAAASASAAAASAAASAACASPAATAASGAAASSASAAAAS
AAAAPNNGQNKSLAAAAPNGNSSSNSWEEGSSGSSSDEEHGGGGMRVGPQYQAVVPDFDP
AKLARRSQERDNLGMLVWSPNQNLSEAKLDEYIAIAKEKHGYNMEQALGMLFWHKHNIEK
SLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKTFHRIQQMLPDKSIASLVKFYYSWKKTR
TKTSVMDRHARKQKREREESEDELEEANGNNPIDIEVDQNKESKKEVPPTETVPQVKKEK
HSTQAKNRAKRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSVKRQIQNIKQTNS
ALKEKLDGGIEPYRLPEVIQKCNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQV
KNFFVNYRRRFNIDEVLQEWEAEHGKEETNGPSNQKPVKSPDNSIKMPEEEDEAPVLDVR
YASAS

BDBM50586372

n/a

Name

BDBM50586372

Synonyms:

CHEMBL5085737

Type

Small organic molecule

Emp. Form.

C74H116N26O16S4

Mol. Mass.

1754.137

SMILES

CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)OCCSSCCn2cc(COc3cccc(OCc4cn(CCSSCCOC(=O)NCCCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC1=O)C(C)C)C(N)=O)nn4)c3)nn2 |r|

Structure