Reaction Details |
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Target | Dual specificity protein kinase CLK2 |
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Ligand | BDBM50590214 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2195621 (CHEMBL5108137) |
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IC50 | 124±n/a nM |
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Citation | Gulati, A; Yeung, CS; Lapointe, B; Kattar, SD; Gunaydin, H; Scott, JD; Childers, KK; Methot, JL; Simov, V; Kurukulasuriya, R; Pio, B; Morriello, GJ; Liu, P; Tang, H; Neelamkavil, S; Wood, HB; Rada, VL; Ardolino, MJ; Yan, XC; Palte, R; Otte, K; Faltus, R; Woodhouse, J; Hegde, LG; Ciaccio, P; Minnihan, EC; DiMauro, EF; Fell, MJ; Fuller, PH; Ellis, JM Optimization of brain-penetrant picolinamide derived leucine-rich repeat kinase 2 (LRRK2) inhibitors. RSC Med Chem12:1164-1173 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dual specificity protein kinase CLK2 |
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Name: | Dual specificity protein kinase CLK2 |
Synonyms: | 2.7.12.1 | CDC-like kinase 2 | CDC-like kinase 2 (CLK2) | CDC2-like kinase 2 (CLK2) | CLK2 | CLK2_HUMAN |
Type: | n/a |
Mol. Mass.: | 60128.79 |
Organism: | Homo sapiens (Human) |
Description: | P49760 |
Residue: | 499 |
Sequence: | MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYD
DRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRR
RRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQC
VDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMC
ISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVN
SDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQ
PCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLD
WDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFA
RLRAEPPNKLWDSSRDISR
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BDBM50590214 |
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n/a |
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Name | BDBM50590214 |
Synonyms: | CHEMBL5208974 |
Type | Small organic molecule |
Emp. Form. | C22H26N6O2 |
Mol. Mass. | 406.4808 |
SMILES | C[C@H]1CN(C[C@@H](C)O1)c1cc(NC(=O)c2cccc(n2)-c2cnn(C)c2)c(C)cn1 |r| |
Structure |
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