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TargetGonadotropin-releasing hormone receptor
LigandBDBM50162035
Substrate/Competitorn/a
Meas. Tech.ChEMBL_302845 (CHEMBL827890)
Ki 15±n/a nM
Citation Tucci, FCZhu, YFStruthers, RSGuo, ZGross, TDRowbottom, MWAcevedo, OGao, YSaunders, JXie, QReinhart, GJLiu, XJLing, NBonneville, AKChen, TBozigian, HChen, C 3-[(2R)-Amino-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)- 6-methylpyrimidin-2,4-dione (NBI 42902) as a potent and orally active antagonist of the human gonadotropin-releasing hormone receptor. Design, synthesis, and in vitro and in vivo characterization. J Med Chem48:1169-78 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Gonadotropin-releasing hormone receptor
Name:Gonadotropin-releasing hormone receptor
Synonyms:GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH)
Type:Enzyme
Mol. Mass.:37749.45
Organism:Homo sapiens (Human)
Description:P30968
Residue:328
Sequence:
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKL
QKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRM
IHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTR
VLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRL
SDPVNHFFFLFAFLNPCFDPLIYGYFSL
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  Blast E-value cutoff:
BDBM50162035
n/a
NameBDBM50162035
Synonyms:1-(2,6-Difluoro-benzyl)-3-((S)-2-dimethylamino-2-phenyl-ethyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione | CHEMBL361128
TypeSmall organic molecule
Emp. Form.C29H28F3N3O3
Mol. Mass.523.5461
SMILESCOc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@@H](N(C)C)c2ccccc2)c1=O |wU:26.28,(2.94,6.11,;4.27,5.36,;4.27,3.82,;5.61,3.03,;5.61,1.49,;4.27,.74,;2.95,1.51,;2.94,3.05,;1.59,3.8,;1.59,.74,;1.59,-.8,;2.95,-1.57,;.28,-1.57,;.28,-3.09,;1.59,-3.86,;2.94,-3.09,;1.59,-2.32,;4.28,-3.86,;4.28,-5.4,;2.94,-6.17,;1.59,-5.4,;.26,-6.17,;-1.04,-.8,;-2.38,-1.57,;-1.04,.74,;-2.38,1.51,;-3.71,.74,;-3.71,-.8,;-3.73,-2.34,;-5.04,-1.57,;-5.06,1.51,;-6.37,.72,;-7.72,1.49,;-7.72,3.03,;-6.39,3.8,;-5.06,3.05,;.28,1.51,;.28,3.05,)|
Structure
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