| Reaction Details |
|---|
 | Report a problem with these data |
| Target | RAC-gamma serine/threonine-protein kinase |
|---|
| Ligand | BDBM50591182 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2199525 (CHEMBL5112041) |
|---|
| EC50 | 34±n/a nM |
|---|
| Citation |  Xu, F; Zhang, X; Chen, Z; He, S; Guo, J; Yu, L; Wang, Y; Hou, C; Ai-Furas, H; Zheng, Z; Smaill, JB; Patterson, AV; Zhang, ZM; Chen, L; Ren, X; Ding, K Discovery of Isoform-Selective Akt3 Degraders Overcoming Osimertinib-Induced Resistance in Non-Small Cell Lung Cancer Cells. J Med Chem65:14032-14048 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| RAC-gamma serine/threonine-protein kinase |
|---|
| Name: | RAC-gamma serine/threonine-protein kinase |
|---|
| Synonyms: | AKT3 | AKT3_HUMAN | PKB gamma | PKBG | Protein kinase Akt-3 | Protein kinase B (Akt 3) | Protein kinase B, gamma | RAC-PK-gamma | RAC-gamma serine/threonine-protein kinase | STK-2 | Serine/threonine-protein kinase AKT | Serine/threonine-protein kinase AKT3 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 55769.36 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 479 |
|---|
| Sequence: | MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQ
LMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCS
PTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILK
KEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRE
RVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDA
ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM
EDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVP
PFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSYSASGRE
|
|
|
|---|
| BDBM50591182 |
|---|
| n/a |
|---|
| Name | BDBM50591182 |
|---|
| Synonyms: | CHEMBL5187719 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C52H72N8O4 |
|---|
| Mol. Mass. | 873.1793 |
|---|
| SMILES | CCC(=O)Nc1cccc(c1)-n1c2nc(Nc3ccc(cc3OC)N3CCN(CCCCCCCCCCCCNC(=O)CC45CC6CC(CC(C6)C4)C5)CC3)ncc2c(C)cc1=O |TLB:47:48:45.46.51:52,THB:47:46:52:53.48.49,49:48:45:51.50.52,49:50:45:53.48.47| |
|---|
| Structure | 
|
|---|
Search and Browse
