Found 700 hits with Last Name = 'patterson' and Initial = 'av' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM397428
(US9987278, Compound Reference 38)Show SMILES CCCNc1nc(Nc2ccc(cc2)C#N)ncc1C#CCCCNC(=O)[C@H](C)N(C)C(=O)\C=C\CN(C)C |r| Show InChI InChI=1S/C29H38N8O2/c1-6-17-31-27-24(21-33-29(35-27)34-25-15-13-23(20-30)14-16-25)11-8-7-9-18-32-28(39)22(2)37(5)26(38)12-10-19-36(3)4/h10,12-16,21-22H,6-7,9,17-19H2,1-5H3,(H,32,39)(H2,31,33,34,35)/b12-10+/t22-/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01719 BindingDB Entry DOI: 10.7270/Q2HQ43WX |
More data for this Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM431867
(US10550114, Compound 1a)Show SMILES C=CC(=O)Nc1ccc2[nH]c(=O)n(C3CCN(Cc4ccc(cc4)-c4nc5cc[nH]c(=O)c5cc4-c4ccccc4)CC3)c2c1 Show InChI InChI=1S/C36H32N6O3/c1-2-33(43)38-26-12-13-31-32(20-26)42(36(45)40-31)27-15-18-41(19-16-27)22-23-8-10-25(11-9-23)34-28(24-6-4-3-5-7-24)21-29-30(39-34)14-17-37-35(29)44/h2-14,17,20-21,27H,1,15-16,18-19,22H2,(H,37,44)(H,38,43)(H,40,45) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01719 BindingDB Entry DOI: 10.7270/Q2HQ43WX |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM397428
(US9987278, Compound Reference 38)Show SMILES CCCNc1nc(Nc2ccc(cc2)C#N)ncc1C#CCCCNC(=O)[C@H](C)N(C)C(=O)\C=C\CN(C)C |r| Show InChI InChI=1S/C29H38N8O2/c1-6-17-31-27-24(21-33-29(35-27)34-25-15-13-23(20-30)14-16-25)11-8-7-9-18-32-28(39)22(2)37(5)26(38)12-10-19-36(3)4/h10,12-16,21-22H,6-7,9,17-19H2,1-5H3,(H,32,39)(H2,31,33,34,35)/b12-10+/t22-/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01719 BindingDB Entry DOI: 10.7270/Q2HQ43WX |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50260190
(CHEMBL4100258)Show SMILES COc1ccc(Nc2ncc3CN(C(=O)N(C4CCN(CC4)C(=O)\C=C\CN(C)C)c3n2)c2c(Cl)c(OC)cc(OC)c2Cl)cc1 Show InChI InChI=1S/C32H37Cl2N7O5/c1-38(2)14-6-7-26(42)39-15-12-22(13-16-39)41-30-20(18-35-31(37-30)36-21-8-10-23(44-3)11-9-21)19-40(32(41)43)29-27(33)24(45-4)17-25(46-5)28(29)34/h6-11,17-18,22H,12-16,19H2,1-5H3,(H,35,36,37)/b7-6+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.280 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
| Assay Description Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ... |
Eur J Med Chem 135: 531-543 (2017)
Article DOI: 10.1016/j.ejmech.2017.04.049 BindingDB Entry DOI: 10.7270/Q2K076QF |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Homo sapiens (Human)) | BDBM50604182
(CHEMBL5194425)Show SMILES C[C@@H](Oc1ccc2[nH]nc(Nc3c(F)cc(cc3NC(=O)C=C)N3CCC(CC3)N3CCOCC3)c2c1)c1c(Cl)cncc1Cl |r| | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00096 BindingDB Entry DOI: 10.7270/Q2K078BB |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50260193
(CHEMBL4092354)Show SMILES CNc1ncc2CN(C(=O)N(C3CCN(CC3)C(=O)\C=C\CN(C)C)c2n1)c1c(Cl)c(OC)cc(OC)c1Cl Show InChI InChI=1S/C26H33Cl2N7O4/c1-29-25-30-14-16-15-34(23-21(27)18(38-4)13-19(39-5)22(23)28)26(37)35(24(16)31-25)17-8-11-33(12-9-17)20(36)7-6-10-32(2)3/h6-7,13-14,17H,8-12,15H2,1-5H3,(H,29,30,31)/b7-6+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.730 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
| Assay Description Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ... |
Eur J Med Chem 135: 531-543 (2017)
Article DOI: 10.1016/j.ejmech.2017.04.049 BindingDB Entry DOI: 10.7270/Q2K076QF |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50260185
(CHEMBL4096041)Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccccc4)nc3N(C3CCN(CC3)C(=O)\C=C\CN(C)C)C2=O)c1Cl Show InChI InChI=1S/C31H35Cl2N7O4/c1-37(2)14-8-11-25(41)38-15-12-22(13-16-38)40-29-20(18-34-30(36-29)35-21-9-6-5-7-10-21)19-39(31(40)42)28-26(32)23(43-3)17-24(44-4)27(28)33/h5-11,17-18,22H,12-16,19H2,1-4H3,(H,34,35,36)/b11-8+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 0.840 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
| Assay Description Inhibition of human recombinant cytoplasmic His-tagged FGFR2 (403 to 822 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by FRET-ba... |
Eur J Med Chem 135: 531-543 (2017)
Article DOI: 10.1016/j.ejmech.2017.04.049 BindingDB Entry DOI: 10.7270/Q2K076QF |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50260181
(CHEMBL4077029)Show SMILES COc1ccccc1Nc1ncc2CN(C(=O)N(C3CCN(CC3)C(=O)\C=C\CN(C)C)c2n1)c1c(Cl)c(OC)cc(OC)c1Cl Show InChI InChI=1S/C32H37Cl2N7O5/c1-38(2)14-8-11-26(42)39-15-12-21(13-16-39)41-30-20(18-35-31(37-30)36-22-9-6-7-10-23(22)44-3)19-40(32(41)43)29-27(33)24(45-4)17-25(46-5)28(29)34/h6-11,17-18,21H,12-16,19H2,1-5H3,(H,35,36,37)/b11-8+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.910 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
| Assay Description Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ... |
Eur J Med Chem 135: 531-543 (2017)
Article DOI: 10.1016/j.ejmech.2017.04.049 BindingDB Entry DOI: 10.7270/Q2K076QF |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50260182
(CHEMBL4092508)Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccc(F)cc4)nc3N(C3CCN(CC3)C(=O)\C=C\CN(C)C)C2=O)c1Cl Show InChI InChI=1S/C31H34Cl2FN7O4/c1-38(2)13-5-6-25(42)39-14-11-22(12-15-39)41-29-19(17-35-30(37-29)36-21-9-7-20(34)8-10-21)18-40(31(41)43)28-26(32)23(44-3)16-24(45-4)27(28)33/h5-10,16-17,22H,11-15,18H2,1-4H3,(H,35,36,37)/b6-5+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.990 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
| Assay Description Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ... |
Eur J Med Chem 135: 531-543 (2017)
Article DOI: 10.1016/j.ejmech.2017.04.049 BindingDB Entry DOI: 10.7270/Q2K076QF |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50260185
(CHEMBL4096041)Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccccc4)nc3N(C3CCN(CC3)C(=O)\C=C\CN(C)C)C2=O)c1Cl Show InChI InChI=1S/C31H35Cl2N7O4/c1-37(2)14-8-11-25(41)38-15-12-22(13-16-38)40-29-20(18-34-30(36-29)35-21-9-6-5-7-10-21)19-39(31(40)42)28-26(32)23(43-3)17-24(44-4)27(28)33/h5-11,17-18,22H,12-16,19H2,1-4H3,(H,34,35,36)/b11-8+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
| Assay Description Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ... |
Eur J Med Chem 135: 531-543 (2017)
Article DOI: 10.1016/j.ejmech.2017.04.049 BindingDB Entry DOI: 10.7270/Q2K076QF |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50260188
(CHEMBL4069509)Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC(C)C)nc3N(C3CCN(CC3)C(=O)\C=C\CN(C)C)C2=O)c1Cl Show InChI InChI=1S/C28H37Cl2N7O4/c1-17(2)32-27-31-15-18-16-36(25-23(29)20(40-5)14-21(41-6)24(25)30)28(39)37(26(18)33-27)19-9-12-35(13-10-19)22(38)8-7-11-34(3)4/h7-8,14-15,17,19H,9-13,16H2,1-6H3,(H,31,32,33)/b8-7+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
| Assay Description Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ... |
Eur J Med Chem 135: 531-543 (2017)
Article DOI: 10.1016/j.ejmech.2017.04.049 BindingDB Entry DOI: 10.7270/Q2K076QF |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50260192
(CHEMBL4088313)Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CCCCC4)nc3N(C3CCN(CC3)C(=O)\C=C\CN(C)C)C2=O)c1Cl Show InChI InChI=1S/C31H41Cl2N7O4/c1-37(2)14-8-11-25(41)38-15-12-22(13-16-38)40-29-20(18-34-30(36-29)35-21-9-6-5-7-10-21)19-39(31(40)42)28-26(32)23(43-3)17-24(44-4)27(28)33/h8,11,17-18,21-22H,5-7,9-10,12-16,19H2,1-4H3,(H,34,35,36)/b11-8+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
| Assay Description Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ... |
Eur J Med Chem 135: 531-543 (2017)
Article DOI: 10.1016/j.ejmech.2017.04.049 BindingDB Entry DOI: 10.7270/Q2K076QF |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50260191
(CHEMBL4103795)Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4cccc(C)c4)nc3N(C3CCN(CC3)C(=O)\C=C\CN(C)C)C2=O)c1Cl Show InChI InChI=1S/C32H37Cl2N7O4/c1-20-8-6-9-22(16-20)36-31-35-18-21-19-40(29-27(33)24(44-4)17-25(45-5)28(29)34)32(43)41(30(21)37-31)23-11-14-39(15-12-23)26(42)10-7-13-38(2)3/h6-10,16-18,23H,11-15,19H2,1-5H3,(H,35,36,37)/b10-7+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
| Assay Description Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ... |
Eur J Med Chem 135: 531-543 (2017)
Article DOI: 10.1016/j.ejmech.2017.04.049 BindingDB Entry DOI: 10.7270/Q2K076QF |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50260187
(CHEMBL4096738)Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CCOC4)nc3N(C3CCN(CC3)C(=O)\C=C\CN(C)C)C2=O)c1Cl Show InChI InChI=1S/C29H37Cl2N7O5/c1-35(2)10-5-6-23(39)36-11-7-20(8-12-36)38-27-18(15-32-28(34-27)33-19-9-13-43-17-19)16-37(29(38)40)26-24(30)21(41-3)14-22(42-4)25(26)31/h5-6,14-15,19-20H,7-13,16-17H2,1-4H3,(H,32,33,34)/b6-5+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
| Assay Description Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ... |
Eur J Med Chem 135: 531-543 (2017)
Article DOI: 10.1016/j.ejmech.2017.04.049 BindingDB Entry DOI: 10.7270/Q2K076QF |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50260184
(CHEMBL4068733)Show SMILES COc1cccc(Nc2ncc3CN(C(=O)N(C4CCN(CC4)C(=O)\C=C\CN(C)C)c3n2)c2c(Cl)c(OC)cc(OC)c2Cl)c1 Show InChI InChI=1S/C32H37Cl2N7O5/c1-38(2)13-7-10-26(42)39-14-11-22(12-15-39)41-30-20(18-35-31(37-30)36-21-8-6-9-23(16-21)44-3)19-40(32(41)43)29-27(33)24(45-4)17-25(46-5)28(29)34/h6-10,16-18,22H,11-15,19H2,1-5H3,(H,35,36,37)/b10-7+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
| Assay Description Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ... |
Eur J Med Chem 135: 531-543 (2017)
Article DOI: 10.1016/j.ejmech.2017.04.049 BindingDB Entry DOI: 10.7270/Q2K076QF |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50525939
(Balversa | Erdafitinib | Jnj-42756493)Show SMILES COc1cc(OC)cc(c1)N(CCNC(C)C)c1ccc2ncc(nc2c1)-c1cnn(C)c1 Show InChI InChI=1S/C25H30N6O2/c1-17(2)26-8-9-31(20-10-21(32-4)13-22(11-20)33-5)19-6-7-23-24(12-19)29-25(15-27-23)18-14-28-30(3)16-18/h6-7,10-17,26H,8-9H2,1-5H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description Inhibition of N-terminal GST-tagged recombinant human FGFR1 (456 to 765 amino acids) incubated for 60 mins by time-resolved fluorescence kinase assay |
J Med Chem 62: 2905-2915 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01531 BindingDB Entry DOI: 10.7270/Q2RX9GHP |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50260190
(CHEMBL4100258)Show SMILES COc1ccc(Nc2ncc3CN(C(=O)N(C4CCN(CC4)C(=O)\C=C\CN(C)C)c3n2)c2c(Cl)c(OC)cc(OC)c2Cl)cc1 Show InChI InChI=1S/C32H37Cl2N7O5/c1-38(2)14-6-7-26(42)39-15-12-22(13-16-39)41-30-20(18-35-31(37-30)36-21-8-10-23(44-3)11-9-21)19-40(32(41)43)29-27(33)24(45-4)17-25(46-5)28(29)34/h6-11,17-18,22H,12-16,19H2,1-5H3,(H,35,36,37)/b7-6+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
| Assay Description Inhibition of human recombinant cytoplasmic His-tagged FGFR2 (403 to 822 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by FRET-ba... |
Eur J Med Chem 135: 531-543 (2017)
Article DOI: 10.1016/j.ejmech.2017.04.049 BindingDB Entry DOI: 10.7270/Q2K076QF |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Homo sapiens (Human)) | BDBM249396
(US10537571, Compound 108 | US10562888, Compound 10...)Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1 Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | <1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description Inhibition of human FGFR4 using Poly [E,Y] 4:1 substrate pre-incubated for 15 to 60 mins followed by ATP and [gamma33P]-ATP addition |
J Med Chem 62: 2905-2915 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01531 BindingDB Entry DOI: 10.7270/Q2RX9GHP |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM249396
(US10537571, Compound 108 | US10562888, Compound 10...)Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1 Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | <1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01719 BindingDB Entry DOI: 10.7270/Q2HQ43WX |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50260183
(CHEMBL4079538)Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4cccc(F)c4)nc3N(C3CCN(CC3)C(=O)\C=C\CN(C)C)C2=O)c1Cl Show InChI InChI=1S/C31H34Cl2FN7O4/c1-38(2)12-6-9-25(42)39-13-10-22(11-14-39)41-29-19(17-35-30(37-29)36-21-8-5-7-20(34)15-21)18-40(31(41)43)28-26(32)23(44-3)16-24(45-4)27(28)33/h5-9,15-17,22H,10-14,18H2,1-4H3,(H,35,36,37)/b9-6+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
| Assay Description Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ... |
Eur J Med Chem 135: 531-543 (2017)
Article DOI: 10.1016/j.ejmech.2017.04.049 BindingDB Entry DOI: 10.7270/Q2K076QF |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM161389
(US10124003, Ref. Ex. Compound 3 | US10835536, Ex. ...)Show SMILES COc1cc(OC)cc(c1)C#Cc1nn([C@H]2CCN(C2)C(=O)C=C)c2ncnc(N)c12 |r| Show InChI InChI=1S/C22H22N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28)6-5-14-9-16(30-2)11-17(10-14)31-3/h4,9-11,13,15H,1,7-8,12H2,2-3H3,(H2,23,24,25)/t15-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01719 BindingDB Entry DOI: 10.7270/Q2HQ43WX |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50260186
(CHEMBL4060079)Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CCOCC4)nc3N(C3CCN(CC3)C(=O)\C=C\CN(C)C)C2=O)c1Cl Show InChI InChI=1S/C30H39Cl2N7O5/c1-36(2)11-5-6-24(40)37-12-7-21(8-13-37)39-28-19(17-33-29(35-28)34-20-9-14-44-15-10-20)18-38(30(39)41)27-25(31)22(42-3)16-23(43-4)26(27)32/h5-6,16-17,20-21H,7-15,18H2,1-4H3,(H,33,34,35)/b6-5+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
| Assay Description Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ... |
Eur J Med Chem 135: 531-543 (2017)
Article DOI: 10.1016/j.ejmech.2017.04.049 BindingDB Entry DOI: 10.7270/Q2K076QF |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Homo sapiens (Human)) | BDBM50604180
(CHEMBL5169893)Show SMILES C[C@@H](Oc1ccc2[nH]nc(Nc3c(F)cc(cc3NC(=O)C=C)N3CCN(C)CC3)c2c1)c1c(Cl)cncc1Cl |r| | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00096 BindingDB Entry DOI: 10.7270/Q2K078BB |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50260192
(CHEMBL4088313)Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CCCCC4)nc3N(C3CCN(CC3)C(=O)\C=C\CN(C)C)C2=O)c1Cl Show InChI InChI=1S/C31H41Cl2N7O4/c1-37(2)14-8-11-25(41)38-15-12-22(13-16-38)40-29-20(18-34-30(36-29)35-21-9-6-5-7-10-21)19-39(31(40)42)28-26(32)23(43-3)17-24(44-4)27(28)33/h8,11,17-18,21-22H,5-7,9-10,12-16,19H2,1-4H3,(H,34,35,36)/b11-8+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
| Assay Description Inhibition of human recombinant cytoplasmic His-tagged FGFR2 (403 to 822 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by FRET-ba... |
Eur J Med Chem 135: 531-543 (2017)
Article DOI: 10.1016/j.ejmech.2017.04.049 BindingDB Entry DOI: 10.7270/Q2K076QF |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50260182
(CHEMBL4092508)Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccc(F)cc4)nc3N(C3CCN(CC3)C(=O)\C=C\CN(C)C)C2=O)c1Cl Show InChI InChI=1S/C31H34Cl2FN7O4/c1-38(2)13-5-6-25(42)39-14-11-22(12-15-39)41-29-19(17-35-30(37-29)36-21-9-7-20(34)8-10-21)18-40(31(41)43)28-26(32)23(44-3)16-24(45-4)27(28)33/h5-10,16-17,22H,11-15,18H2,1-4H3,(H,35,36,37)/b6-5+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
| Assay Description Inhibition of human recombinant cytoplasmic His-tagged FGFR2 (403 to 822 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by FRET-ba... |
Eur J Med Chem 135: 531-543 (2017)
Article DOI: 10.1016/j.ejmech.2017.04.049 BindingDB Entry DOI: 10.7270/Q2K076QF |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50260184
(CHEMBL4068733)Show SMILES COc1cccc(Nc2ncc3CN(C(=O)N(C4CCN(CC4)C(=O)\C=C\CN(C)C)c3n2)c2c(Cl)c(OC)cc(OC)c2Cl)c1 Show InChI InChI=1S/C32H37Cl2N7O5/c1-38(2)13-7-10-26(42)39-14-11-22(12-15-39)41-30-20(18-35-31(37-30)36-21-8-6-9-23(16-21)44-3)19-40(32(41)43)29-27(33)24(45-4)17-25(46-5)28(29)34/h6-10,16-18,22H,11-15,19H2,1-5H3,(H,35,36,37)/b10-7+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
| Assay Description Inhibition of human recombinant cytoplasmic His-tagged FGFR2 (403 to 822 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by FRET-ba... |
Eur J Med Chem 135: 531-543 (2017)
Article DOI: 10.1016/j.ejmech.2017.04.049 BindingDB Entry DOI: 10.7270/Q2K076QF |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM161389
(US10124003, Ref. Ex. Compound 3 | US10835536, Ex. ...)Show SMILES COc1cc(OC)cc(c1)C#Cc1nn([C@H]2CCN(C2)C(=O)C=C)c2ncnc(N)c12 |r| Show InChI InChI=1S/C22H22N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28)6-5-14-9-16(30-2)11-17(10-14)31-3/h4,9-11,13,15H,1,7-8,12H2,2-3H3,(H2,23,24,25)/t15-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01719 BindingDB Entry DOI: 10.7270/Q2HQ43WX |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Homo sapiens (Human)) | BDBM50607474
(CHEMBL5220871)Show SMILES CC(C)Oc1cc(NC(=O)c2cn(C)c3ccc(C=O)nc23)ncc1C#N | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01319 BindingDB Entry DOI: 10.7270/Q2154N58 |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50260193
(CHEMBL4092354)Show SMILES CNc1ncc2CN(C(=O)N(C3CCN(CC3)C(=O)\C=C\CN(C)C)c2n1)c1c(Cl)c(OC)cc(OC)c1Cl Show InChI InChI=1S/C26H33Cl2N7O4/c1-29-25-30-14-16-15-34(23-21(27)18(38-4)13-19(39-5)22(23)28)26(37)35(24(16)31-25)17-8-11-33(12-9-17)20(36)7-6-10-32(2)3/h6-7,13-14,17H,8-12,15H2,1-5H3,(H,29,30,31)/b7-6+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
| Assay Description Inhibition of human recombinant cytoplasmic His-tagged FGFR2 (403 to 822 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by FRET-ba... |
Eur J Med Chem 135: 531-543 (2017)
Article DOI: 10.1016/j.ejmech.2017.04.049 BindingDB Entry DOI: 10.7270/Q2K076QF |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50260191
(CHEMBL4103795)Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4cccc(C)c4)nc3N(C3CCN(CC3)C(=O)\C=C\CN(C)C)C2=O)c1Cl Show InChI InChI=1S/C32H37Cl2N7O4/c1-20-8-6-9-22(16-20)36-31-35-18-21-19-40(29-27(33)24(44-4)17-25(45-5)28(29)34)32(43)41(30(21)37-31)23-11-14-39(15-12-23)26(42)10-7-13-38(2)3/h6-10,16-18,23H,11-15,19H2,1-5H3,(H,35,36,37)/b10-7+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
| Assay Description Inhibition of human recombinant cytoplasmic His-tagged FGFR2 (403 to 822 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by FRET-ba... |
Eur J Med Chem 135: 531-543 (2017)
Article DOI: 10.1016/j.ejmech.2017.04.049 BindingDB Entry DOI: 10.7270/Q2K076QF |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50260207
(CHEMBL4102560)Show SMILES CNc1ncc2CN(C(=O)N(CCCNC(=O)\C=C\CN(C)C)c2n1)c1c(Cl)c(OC)cc(OC)c1Cl Show InChI InChI=1S/C24H31Cl2N7O4/c1-27-23-29-13-15-14-33(21-19(25)16(36-4)12-17(37-5)20(21)26)24(35)32(22(15)30-23)11-7-9-28-18(34)8-6-10-31(2)3/h6,8,12-13H,7,9-11,14H2,1-5H3,(H,28,34)(H,27,29,30)/b8-6+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
| Assay Description Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ... |
Eur J Med Chem 135: 531-543 (2017)
Article DOI: 10.1016/j.ejmech.2017.04.049 BindingDB Entry DOI: 10.7270/Q2K076QF |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50260199
(CHEMBL4066038)Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4cc(F)cc(F)c4)nc3N(C3CCN(CC3)C(=O)\C=C\CN(C)C)C2=O)c1Cl Show InChI InChI=1S/C31H33Cl2F2N7O4/c1-39(2)9-5-6-25(43)40-10-7-22(8-11-40)42-29-18(16-36-30(38-29)37-21-13-19(34)12-20(35)14-21)17-41(31(42)44)28-26(32)23(45-3)15-24(46-4)27(28)33/h5-6,12-16,22H,7-11,17H2,1-4H3,(H,36,37,38)/b6-5+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
| Assay Description Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ... |
Eur J Med Chem 135: 531-543 (2017)
Article DOI: 10.1016/j.ejmech.2017.04.049 BindingDB Entry DOI: 10.7270/Q2K076QF |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50260183
(CHEMBL4079538)Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4cccc(F)c4)nc3N(C3CCN(CC3)C(=O)\C=C\CN(C)C)C2=O)c1Cl Show InChI InChI=1S/C31H34Cl2FN7O4/c1-38(2)12-6-9-25(42)39-13-10-22(11-14-39)41-29-19(17-35-30(37-29)36-21-8-5-7-20(34)15-21)18-40(31(41)43)28-26(32)23(44-3)16-24(45-4)27(28)33/h5-9,15-17,22H,10-14,18H2,1-4H3,(H,35,36,37)/b9-6+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
| Assay Description Inhibition of human recombinant cytoplasmic His-tagged FGFR2 (403 to 822 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by FRET-ba... |
Eur J Med Chem 135: 531-543 (2017)
Article DOI: 10.1016/j.ejmech.2017.04.049 BindingDB Entry DOI: 10.7270/Q2K076QF |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Homo sapiens (Human)) | BDBM209325
(US11136320, Reference Compound | US9266883, 83)Show SMILES COCCNc1cc(NC(=O)N2CCCc3cc(CN4CCN(C)CC4=O)c(C=O)nc23)ncc1C#N Show InChI InChI=1S/C25H30N8O4/c1-31-7-8-32(23(35)15-31)14-18-10-17-4-3-6-33(24(17)29-21(18)16-34)25(36)30-22-11-20(27-5-9-37-2)19(12-26)13-28-22/h10-11,13,16H,3-9,14-15H2,1-2H3,(H2,27,28,30,36) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01719 BindingDB Entry DOI: 10.7270/Q2HQ43WX |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Fibroblast growth factor receptor 4
(Homo sapiens (Human)) | BDBM50607473
(CHEMBL5218602)Show SMILES CN1CCN(CCNc2cc(NC(=O)c3cn(C)c4ccc(C=O)nc34)ncc2C#N)CC1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01319 BindingDB Entry DOI: 10.7270/Q2154N58 |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50260197
(CHEMBL4072483)Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccc(F)c(Cl)c4)nc3N(C3CCN(CC3)C(=O)\C=C\CN(C)C)C2=O)c1Cl Show InChI InChI=1S/C31H33Cl3FN7O4/c1-39(2)11-5-6-25(43)40-12-9-20(10-13-40)42-29-18(16-36-30(38-29)37-19-7-8-22(35)21(32)14-19)17-41(31(42)44)28-26(33)23(45-3)15-24(46-4)27(28)34/h5-8,14-16,20H,9-13,17H2,1-4H3,(H,36,37,38)/b6-5+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
| Assay Description Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ... |
Eur J Med Chem 135: 531-543 (2017)
Article DOI: 10.1016/j.ejmech.2017.04.049 BindingDB Entry DOI: 10.7270/Q2K076QF |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50322535
(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)Show SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4cccnn34)cc2C(F)(F)F)CC1 Show InChI InChI=1S/C29H27F3N6O/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank PDB Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description Inhibition of human FGFR1 using poly[Glu:Tyr] (4:1) substrate and ATP and [gamma33P]-ATP |
J Med Chem 62: 2905-2915 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01531 BindingDB Entry DOI: 10.7270/Q2RX9GHP |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50322535
(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)Show SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4cccnn34)cc2C(F)(F)F)CC1 Show InChI InChI=1S/C29H27F3N6O/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank PDB Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description Inhibition of human FGFR2 using poly[Glu:Tyr] (4:1) substrate and ATP and [gamma33P]-ATP |
J Med Chem 62: 2905-2915 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01531 BindingDB Entry DOI: 10.7270/Q2RX9GHP |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Fibroblast growth factor receptor 4
(Homo sapiens (Human)) | BDBM333185
(US10196436, Compound 35)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(Nc3c(Cl)cccc3NC(=O)C=C)ncc2c1 Show InChI InChI=1S/C25H19Cl3N4O3/c1-4-20(33)30-17-7-5-6-15(26)24(17)32-25-29-12-14-10-13(8-9-16(14)31-25)21-22(27)18(34-2)11-19(35-3)23(21)28/h4-12H,1H2,2-3H3,(H,30,33)(H,29,31,32) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00096 BindingDB Entry DOI: 10.7270/Q2K078BB |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50403060
(CHEMBL2216830)Show SMILES CCN(CC)CCCCNc1ncc2CN(C(=O)N(Cc3cccc(NC(=O)C=C)c3)c2n1)c1c(Cl)c(OC)cc(OC)c1Cl Show InChI InChI=1S/C32H39Cl2N7O4/c1-6-26(42)37-23-13-11-12-21(16-23)19-41-30-22(18-36-31(38-30)35-14-9-10-15-39(7-2)8-3)20-40(32(41)43)29-27(33)24(44-4)17-25(45-5)28(29)34/h6,11-13,16-18H,1,7-10,14-15,19-20H2,2-5H3,(H,37,42)(H,35,36,38) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of His-tagged cytoplasmic recombinant human FGFR2 (403 to 822 residues) expressed in baculovirus expression system using Tyr 4 peptide as ... |
ACS Med Chem Lett 8: 543-548 (2017)
Article DOI: 10.1021/acsmedchemlett.7b00091 BindingDB Entry DOI: 10.7270/Q2319Z4P |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50260198
(CHEMBL4099403)Show SMILES COc1cc(Nc2ncc3CN(C(=O)N(C4CCN(CC4)C(=O)\C=C\CN(C)C)c3n2)c2c(Cl)c(OC)cc(OC)c2Cl)ccc1F Show InChI InChI=1S/C32H36Cl2FN7O5/c1-39(2)12-6-7-26(43)40-13-10-21(11-14-40)42-30-19(17-36-31(38-30)37-20-8-9-22(35)23(15-20)45-3)18-41(32(42)44)29-27(33)24(46-4)16-25(47-5)28(29)34/h6-9,15-17,21H,10-14,18H2,1-5H3,(H,36,37,38)/b7-6+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
| Assay Description Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ... |
Eur J Med Chem 135: 531-543 (2017)
Article DOI: 10.1016/j.ejmech.2017.04.049 BindingDB Entry DOI: 10.7270/Q2K076QF |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50403060
(CHEMBL2216830)Show SMILES CCN(CC)CCCCNc1ncc2CN(C(=O)N(Cc3cccc(NC(=O)C=C)c3)c2n1)c1c(Cl)c(OC)cc(OC)c1Cl Show InChI InChI=1S/C32H39Cl2N7O4/c1-6-26(42)37-23-13-11-12-21(16-23)19-41-30-22(18-36-31(38-30)35-14-9-10-15-39(7-2)8-3)20-40(32(41)43)29-27(33)24(44-4)17-25(45-5)28(29)34/h6,11-13,16-18H,1,7-10,14-15,19-20H2,2-5H3,(H,37,42)(H,35,36,38) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
| Assay Description Inhibition of human recombinant cytoplasmic His-tagged FGFR2 (403 to 822 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by FRET-ba... |
Eur J Med Chem 135: 531-543 (2017)
Article DOI: 10.1016/j.ejmech.2017.04.049 BindingDB Entry DOI: 10.7270/Q2K076QF |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50260205
(CHEMBL4061908)Show SMILES CNc1ncc2CN(C(=O)N([C@H]3CCN(C3)C(=O)\C=C\CN(C)C)c2n1)c1c(Cl)c(OC)cc(OC)c1Cl |r| Show InChI InChI=1S/C25H31Cl2N7O4/c1-28-24-29-12-15-13-33(22-20(26)17(37-4)11-18(38-5)21(22)27)25(36)34(23(15)30-24)16-8-10-32(14-16)19(35)7-6-9-31(2)3/h6-7,11-12,16H,8-10,13-14H2,1-5H3,(H,28,29,30)/b7-6+/t16-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
| Assay Description Inhibition of human recombinant His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by ... |
Eur J Med Chem 135: 531-543 (2017)
Article DOI: 10.1016/j.ejmech.2017.04.049 BindingDB Entry DOI: 10.7270/Q2K076QF |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50260186
(CHEMBL4060079)Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CCOCC4)nc3N(C3CCN(CC3)C(=O)\C=C\CN(C)C)C2=O)c1Cl Show InChI InChI=1S/C30H39Cl2N7O5/c1-36(2)11-5-6-24(40)37-12-7-21(8-13-37)39-28-19(17-33-29(35-28)34-20-9-14-44-15-10-20)18-38(30(39)41)27-25(31)22(42-3)16-23(43-4)26(27)32/h5-6,16-17,20-21H,7-15,18H2,1-4H3,(H,33,34,35)/b6-5+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
| Assay Description Inhibition of human recombinant cytoplasmic His-tagged FGFR2 (403 to 822 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by FRET-ba... |
Eur J Med Chem 135: 531-543 (2017)
Article DOI: 10.1016/j.ejmech.2017.04.049 BindingDB Entry DOI: 10.7270/Q2K076QF |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Homo sapiens (Human)) | BDBM50607471
(CHEMBL5218768)Show SMILES CN(C)CCNc1cc(NC(=O)c2cn(C)c3ccc(C=O)nc23)ncc1C#N | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01319 BindingDB Entry DOI: 10.7270/Q2154N58 |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50525939
(Balversa | Erdafitinib | Jnj-42756493)Show SMILES COc1cc(OC)cc(c1)N(CCNC(C)C)c1ccc2ncc(nc2c1)-c1cnn(C)c1 Show InChI InChI=1S/C25H30N6O2/c1-17(2)26-8-9-31(20-10-21(32-4)13-22(11-20)33-5)19-6-7-23-24(12-19)29-25(15-27-23)18-14-28-30(3)16-18/h6-7,10-17,26H,8-9H2,1-5H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description Inhibition of human FGFR2 incubated for 30 mins by time-resolved fluorescence kinase assay |
J Med Chem 62: 2905-2915 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01531 BindingDB Entry DOI: 10.7270/Q2RX9GHP |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Fibroblast growth factor receptor 4
(Homo sapiens (Human)) | BDBM209325
(US11136320, Reference Compound | US9266883, 83)Show SMILES COCCNc1cc(NC(=O)N2CCCc3cc(CN4CCN(C)CC4=O)c(C=O)nc23)ncc1C#N Show InChI InChI=1S/C25H30N8O4/c1-31-7-8-32(23(35)15-31)14-18-10-17-4-3-6-33(24(17)29-21(18)16-34)25(36)30-22-11-20(27-5-9-37-2)19(12-26)13-28-22/h10-11,13,16H,3-9,14-15H2,1-2H3,(H2,27,28,30,36) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01319 BindingDB Entry DOI: 10.7270/Q2154N58 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50189781
(CHEMBL3828009)Show SMILES C[C@@H](Oc1ccc2[nH]nc(\C=C\c3cnn(CCO)c3)c2c1)c1c(Cl)cncc1Cl |r| Show InChI InChI=1S/C21H19Cl2N5O2/c1-13(21-17(22)10-24-11-18(21)23)30-15-3-5-20-16(8-15)19(26-27-20)4-2-14-9-25-28(12-14)6-7-29/h2-5,8-13,29H,6-7H2,1H3,(H,26,27)/b4-2+/t13-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University
Curated by ChEMBL
| Assay Description Inhibition of FGFR2 (unknown origin) using poly[Glu:Tyr] (4:1) substrate and ATP and [gamma33P]-ATP incubated for 30 mins |
J Med Chem 62: 2905-2915 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01531 BindingDB Entry DOI: 10.7270/Q2RX9GHP |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Homo sapiens (Human)) | BDBM50233462
(CHEMBL4065231)Show SMILES COc1cc(OC)c(Cl)c(COc2cnc(Nc3c(Cl)cc(F)cc3NC(=O)C=C)nc2)c1Cl Show InChI InChI=1S/C22H18Cl3FN4O4/c1-4-18(31)29-15-6-11(26)5-14(23)21(15)30-22-27-8-12(9-28-22)34-10-13-19(24)16(32-2)7-17(33-3)20(13)25/h4-9H,1,10H2,2-3H3,(H,29,31)(H,27,28,30) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of His-tagged cytoplasmic recombinant human FGFR4 (781 to 1338 residues) expressed in baculovirus expression system using Tyr 4 peptide as... |
ACS Med Chem Lett 8: 543-548 (2017)
Article DOI: 10.1021/acsmedchemlett.7b00091 BindingDB Entry DOI: 10.7270/Q2319Z4P |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50260188
(CHEMBL4069509)Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC(C)C)nc3N(C3CCN(CC3)C(=O)\C=C\CN(C)C)C2=O)c1Cl Show InChI InChI=1S/C28H37Cl2N7O4/c1-17(2)32-27-31-15-18-16-36(25-23(29)20(40-5)14-21(41-6)24(25)30)28(39)37(26(18)33-27)19-9-12-35(13-10-19)22(38)8-7-11-34(3)4/h7-8,14-15,17,19H,9-13,16H2,1-6H3,(H,31,32,33)/b8-7+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Guangzhou Institutes of Biomedicine and Health
Curated by ChEMBL
| Assay Description Inhibition of human recombinant cytoplasmic His-tagged FGFR2 (403 to 822 residues) expressed in baculovirus using Tyr-4 peptide after 1 hr by FRET-ba... |
Eur J Med Chem 135: 531-543 (2017)
Article DOI: 10.1016/j.ejmech.2017.04.049 BindingDB Entry DOI: 10.7270/Q2K076QF |
More data for this Ligand-Target Pair | |