| Reaction Details |
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 | Report a problem with these data |
| Target | Bifunctional epoxide hydrolase 2 |
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| Ligand | BDBM50591528 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2200646 (CHEMBL5113162) |
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| IC50 | 2400±n/a nM |
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| Citation |  Cerqua, I; Musella, S; Peltner, LK; D'Avino, D; Di Sarno, V; Granato, E; Vestuto, V; Di Matteo, R; Pace, S; Ciaglia, T; Bilancia, R; Smaldone, G; Di Matteo, F; Di Micco, S; Bifulco, G; Pepe, G; Basilicata, MG; Rodriquez, M; Gomez-Monterrey, IM; Campiglia, P; Ostacolo, C; Roviezzo, F; Werz, O; Rossi, A; Bertamino, A Discovery and Optimization of Indoline-Based Compounds as Dual 5-LOX/sEH Inhibitors: J Med Chem65:14456-14480 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bifunctional epoxide hydrolase 2 |
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| Name: | Bifunctional epoxide hydrolase 2 |
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| Synonyms: | Cytosolic epoxide hydrolase 2 | EBifunctional epoxide hydrolase 2 | EPHX2 | Epoxide hydratase | HYES_HUMAN | Lipid-phosphate phosphatase | Soluble epoxide hydrolase (sEH) | epoxide hydrolase 2, cytoplasmic |
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| Type: | Enzyme |
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| Mol. Mass.: | 62613.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P34913 |
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| Residue: | 555 |
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| Sequence: | MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITL
SQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTA
ILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEV
VFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHG
YVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESS
APPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNT
PFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMH
KVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSL
GRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIK
WLDSDARNPPVVSKM
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| BDBM50591528 |
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| n/a |
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| Name | BDBM50591528 |
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| Synonyms: | CHEMBL5207672 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H31N3O2S |
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| Mol. Mass. | 413.576 |
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| SMILES | COCOc1ccc(CN2CCc3cc(NC(=S)NCC(C)(C)C)ccc23)cc1 |
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| Structure | 
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