Reaction Details |
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Target | Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 |
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Ligand | BDBM50165329 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_303742 (CHEMBL829785) |
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Ki | 1.82±n/a nM |
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Citation | Primofiore, G; Da Settimo, F; Taliani, S; Salerno, S; Novellino, E; Greco, G; Cosimelli, B; Besnard, F; Costa, B; Montali, M; Martini, C High affinity central benzodiazepine receptor ligands: synthesis and biological evaluation of a series of phenyltriazolobenzotriazindione derivatives. J Med Chem48:2936-43 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 |
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Name: | Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 |
Synonyms: | GABA receptor alpha-1/beta-2/gamma-2 subunit | GABA-A receptor; alpha-1/beta-2/gamma-2 | GABAA Subunit α1β2γ2 | GABAA Subunit alpha-1, beta-2, gamma-2 |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of EBI is 69455 |
Components: | This complex has 3 components. |
Component 1 |
Name: | Gamma-aminobutyric acid receptor subunit beta-2 |
Synonyms: | GBRB2_RAT | Gabrb-2 | Gabrb2 | Gamma-aminobutyric acid receptor subunit beta-2 (GABA(A) beta-2) |
Type: | Enzyme |
Mol. Mass.: | 54648.97 |
Organism: | Rattus norvegicus (Rat) |
Description: | P63138 |
Residue: | 474 |
Sequence: | MWRVRKRGYFGIWSFPLIIAAVCAQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPV
AVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPDT
YFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIES
YGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLKR
NIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIP
YVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAANANNEKMRLDVNKM
DPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNALER
HVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN
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Component 2 |
Name: | Gamma-aminobutyric acid receptor subunit gamma-2 |
Synonyms: | GBRG2_RAT | Gabrg2 | Gamma-aminobutyric acid receptor subunit gamma-2 (GABA(A) gamma-2) |
Type: | Enzyme |
Mol. Mass.: | 54087.63 |
Organism: | Rattus norvegicus (Rat) |
Description: | P18508 |
Residue: | 466 |
Sequence: | MSSPNTWSTGSTVYSPVFSQKMTLWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKV
PEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTW
YDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYT
LRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFS
FVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAV
PARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVS
NRKPSKDKDKKKKNPAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCF
EDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL
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Component 3 |
Name: | Gamma-aminobutyric acid receptor subunit alpha-1 |
Synonyms: | Benzodiazepine central | Benzodiazepine receptors | GABA A Benzodiazepine | GABA A Benzodiazepine Type I | GABA A Benzodiazepine Type II | GABA A Benzodiazepine Type IIL | GABA A Benzodiazepine Type IIM | GABA A Benzodiazepine omega1 | GABA A Benzodiazepine omega2 | GABA A Benzodiazepine omega5 | GABA A alpha1 | GABA A anti-Alpha1 | GABA receptor alpha-1 subunit | GABA, Chloride, TBOB | GABA-PICROTOXIN | GBRA1_RAT | Gabra-1 | Gabra1 | TBPS |
Type: | Enzyme |
Mol. Mass.: | 51770.21 |
Organism: | Rattus norvegicus (Rat) |
Description: | P62813 |
Residue: | 455 |
Sequence: | MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGL
GERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKI
WTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACP
LKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMT
THFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISAR
NSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPL
IKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDR
LSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ
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BDBM50165329 |
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n/a |
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Name | BDBM50165329 |
Synonyms: | 8-Chloro-2-(4-methoxy-phenyl)-5H-3,3a,5,9b-tetraaza-cyclopenta[a]naphthalene-1,4-dione | CHEMBL191088 |
Type | Small organic molecule |
Emp. Form. | C16H11ClN4O3 |
Mol. Mass. | 342.737 |
SMILES | COc1ccc(cc1)-c1nn2n(c3cc(Cl)ccc3[nH]c2=O)c1=O |
Structure |
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