Reaction Details | |||
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Target | Pro-cathepsin H | ||
Ligand | BDBM50165420 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_306657 (CHEMBL831430) | ||
IC50 | >5000±n/a nM | ||
Citation | Barrett, DG; Catalano, JG; Deaton, DN; Long, ST; McFadyen, RB; Miller, AB; Miller, LR; Wells-Knecht, KJ; Wright, LL A structural screening approach to ketoamide-based inhibitors of cathepsin K. Bioorg Med Chem Lett15:2209-13 (2005) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Pro-cathepsin H | |||
Name: | Pro-cathepsin H | ||
Synonyms: | CATH_HUMAN | CBSP | CPSB | CTSH | Cathepsin H | Cathepsin H heavy chain | Cathepsin H light chain | Cathepsin H mini chain | ||
Type: | PROTEIN | ||
Mol. Mass.: | 37402.31 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_1459870 | ||
Residue: | 335 | ||
Sequence: |
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BDBM50165420 | |||
n/a | |||
Name | BDBM50165420 | ||
Synonyms: | CHEMBL197509 | [(S)-1-((R)-1-Phenyl-ethylaminooxalyl)-pentyl]-carbamic acid adamantan-2-yl ester | ||
Type | Small organic molecule | ||
Emp. Form. | C26H36N2O4 | ||
Mol. Mass. | 440.575 | ||
SMILES | CCCC[C@H](NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)C(=O)N[C@H](C)c1ccccc1 |wD:4.4,24.27,TLB:18:17:15:12.11.13,THB:13:12:9:14.16.15,13:14:9:12.11.18,8:9:15:12.11.13,18:12:9.17.16:15,(1.45,-4.67,;2.78,-3.9,;2.78,-2.36,;4.11,-1.59,;4.11,-.05,;2.78,.72,;1.45,-.05,;1.45,-1.59,;.12,.72,;-1.21,-.05,;-1.23,-1.57,;-2.63,-1.92,;-3.96,-1.43,;-5.15,-2.71,;-3.66,-2.29,;-2.24,-2.85,;-3.66,-.7,;-2.61,.53,;-3.96,.06,;5.44,.72,;5.44,2.26,;6.77,-.05,;6.77,-1.59,;8.12,.72,;9.45,-.05,;10.79,.72,;9.45,-1.59,;8.1,-2.34,;8.1,-3.88,;9.45,-4.65,;10.79,-3.88,;10.78,-2.34,)| | ||
Structure |