| Reaction Details |
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 | Report a problem with these data |
| Target | Gonadotropin-releasing hormone receptor |
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| Ligand | BDBM50166455 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_303284 (CHEMBL828277) |
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| Ki | 660±n/a nM |
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| Citation |  Guo, Z; Chen, Y; Huang, CQ; Gross, TD; Pontillo, J; Rowbottom, MW; Saunders, J; Struthers, S; Tucci, FC; Xie, Q; Wade, W; Zhu, YF; Wu, D; Chen, C Uracils as potent antagonists of the human gonadotropin-releasing hormone receptor without atropisomers. Bioorg Med Chem Lett15:2519-22 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Gonadotropin-releasing hormone receptor |
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| Name: | Gonadotropin-releasing hormone receptor |
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| Synonyms: | GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH) |
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| Type: | Enzyme |
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| Mol. Mass.: | 37749.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30968 |
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| Residue: | 328 |
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| Sequence: | MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKL
QKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRM
IHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTR
VLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRL
SDPVNHFFFLFAFLNPCFDPLIYGYFSL
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| BDBM50166455 |
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| n/a |
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| Name | BDBM50166455 |
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| Synonyms: | 3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-hydroxy-phenyl)-1H-pyrimidine-2,4-dione | CHEMBL370480 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H20F3N3O3 |
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| Mol. Mass. | 467.4398 |
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| SMILES | N[C@@H](Cn1c(=O)c(cn(Cc2c(F)cccc2F)c1=O)-c1cccc(O)c1F)c1ccccc1 |
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| Structure | 
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