Reaction Details |
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Target | Methionine aminopeptidase |
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Ligand | BDBM50169667 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_311781 (CHEMBL826403) |
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IC50 | 76±n/a nM |
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Citation | Cui, YM; Huang, QQ; Xu, J; Chen, LL; Li, JY; Ye, QZ; Li, J; Nan, FJ Identification of potent type I MetAP inhibitors by simple bioisosteric replacement. Part 1: Synthesis and preliminary SAR studies of thiazole-4-carboxylic acid thiazol-2-ylamide derivatives. Bioorg Med Chem Lett15:3732-6 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Methionine aminopeptidase |
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Name: | Methionine aminopeptidase |
Synonyms: | EcMetAP | MAP1_ECOLI | Methionine Aminopeptidase (MAP) | Methionine aminopeptidase | Peptidase M | map |
Type: | Enzyme |
Mol. Mass.: | 29326.96 |
Organism: | Escherichia coli (strain K12) |
Description: | Full-length untagged EcMAP was expressed in E. coli. |
Residue: | 264 |
Sequence: | MAISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACL
GYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTI
MGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEE
PQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVV
TDNGCEILTLRKDDTIPAIISHDE
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BDBM50169667 |
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n/a |
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Name | BDBM50169667 |
Synonyms: | Acetic acid [4-(thiazol-2-ylcarbamoyl)-thiazol-5-ylcarbamoyl]-methyl ester | CHEMBL179431 |
Type | Small organic molecule |
Emp. Form. | C11H10N4O4S2 |
Mol. Mass. | 326.352 |
SMILES | CC(=O)OCC(=O)Nc1scnc1C(=O)Nc1nccs1 |
Structure |
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