| Reaction Details |
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 | Report a problem with these data |
| Target | Aldo-keto reductase family 1 member C4 |
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| Ligand | BDBM50595592 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2217174 (CHEMBL5130306) |
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| IC50 | 750±n/a nM |
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| Citation |  He, S; Liu, Y; Chu, X; Li, Q; Lyu, W; Liu, Y; Xing, S; Feng, F; Liu, W; Guo, Q; Zhao, L; Sun, H Discovery of Novel Aldo-Keto Reductase 1C3 Inhibitors as Chemotherapeutic Potentiators for Cancer Drug Resistance. ACS Med Chem Lett13:1286-1294 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aldo-keto reductase family 1 member C4 |
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| Name: | Aldo-keto reductase family 1 member C4 |
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| Synonyms: | 3-alpha-HSD1 | 3-alpha-Hydroxysteroid Dehydrogenase Type 1 (AKR1C4) | 3-alpha-hydroxysteroid dehydrogenase type I | AK1C4_HUMAN | AKR1C4 | Aldo-keto reductase family 1 member C4 | Aldo-keto reductase family 1 member C4 (AK1C4) | CDR | CHDR | Chlordecone reductase | DD-4 | DD4 | Dihydrodiol dehydrogenase 4 | HAKRA |
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| Type: | Enzyme |
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| Mol. Mass.: | 37068.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P17516 |
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| Residue: | 323 |
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| Sequence: | MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM
ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKP
GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV
LCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN
RNYRYVVMDFLMDHPDYPFSDEY
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| BDBM50595592 |
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| n/a |
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| Name | BDBM50595592 |
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| Synonyms: | CHEMBL5179823 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H23NO6 |
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| Mol. Mass. | 373.3997 |
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| SMILES | CCOc1ccc2OCC(Cc2c1)C(=O)N(C)Cc1cc(C(O)=O)c(C)o1 |
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| Structure | 
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