| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Lysine-specific histone demethylase 1A |
|---|
| Ligand | BDBM50595759 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2217865 (CHEMBL5130997) |
|---|
| IC50 | 444±n/a nM |
|---|
| Citation |  Ota, Y; Itoh, Y; Kurohara, T; Singh, R; Elboray, EE; Hu, C; Zamani, F; Mukherjee, A; Takada, Y; Yamashita, Y; Morita, M; Horinaka, M; Sowa, Y; Masuda, M; Sakai, T; Suzuki, T Cancer-Cell-Selective Targeting by Arylcyclopropylamine-Vorinostat Conjugates. ACS Med Chem Lett13:1568-1573 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Lysine-specific histone demethylase 1A |
|---|
| Name: | Lysine-specific histone demethylase 1A |
|---|
| Synonyms: | AOF2 | BRAF35-HDAC complex protein BHC110 | Flavin-containing amine oxidase domain-containing protein 2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific demethylase 1 (LSD1) | Lysine-specific histone demethylase 1 | Lysine-specific histone demethylase 1 (LSD1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 92901.01 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O60341 |
|---|
| Residue: | 852 |
|---|
| Sequence: | MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTP
RKKEPPRASPPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEY
REMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGVEGAAFQ
SRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEA
PYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSF
GMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKC
PLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQE
KHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLV
KSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFAN
ATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGC
EVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLN
KVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISD
DVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPI
TPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQA
TPGVPAQQSPSM
|
|
|
|---|
| BDBM50595759 |
|---|
| n/a |
|---|
| Name | BDBM50595759 |
|---|
| Synonyms: | CHEMBL5175995 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C43H51N5O6 |
|---|
| Mol. Mass. | 733.8949 |
|---|
| SMILES | CNC(=O)c1cccc(c1)-c1ccc(cc1)[C@@H]1C[C@H]1N(C)CCN(C)C(=O)Oc1ccc(CONC(=O)CCCCCCC(=O)Nc2ccccc2)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
