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TargetElongation of very long chain fatty acids protein 1
LigandBDBM50596155
Substrate/Competitorn/a
Meas. Tech.ChEMBL_2219492 (CHEMBL5132826)
IC50 80±n/a nM
Citation Come, JHSenter, TJClark, MPCourt, JJGale-Day, ZGu, WKrueger, ELiang, JMorris, MNanthakumar, SO'Dowd, HMaltais, FIyer, GAndreassi, JBoucher, CConsidine, TMoody, CSTaylor, WMohanty, AKHuang, YZuccola, HColl, JBonanno, KCGagnon, KJGan, LLu, FGao, HChakilam, AEngtrakul, JSong, BCrawford, DDoyle, EKramer, TVought, BPhillips, JKemper, RSanders, MSwett, RFurey, BWinquist, RBunnage, MEJackson, KLCharifson, PSMagavi, SS Discovery and Optimization of Pyrazole Amides as Inhibitors of ELOVL1. J Med Chem64:17753-17776 (2021) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Elongation of very long chain fatty acids protein 1
Name:Elongation of very long chain fatty acids protein 1
Synonyms:ELOV1_HUMAN | ELOVL1 | SSC1
Type:PROTEIN
Mol. Mass.:32679.45
Organism:Homo sapiens (Human)
Description:ChEMBL_572241
Residue:279
Sequence:
MEAVVNLYQEVMKHADPRIQGYPLMGSPLLMTSILLTYVYFVLSLGPRIMANRKPFQLRG
FMIVYNFSLVALSLYIVYEFLMSGWLSTYTWRCDPVDYSNSPEALRMVRVAWLFLFSKFI
ELMDTVIFILRKKDGQVTFLHVFHHSVLPWSWWWGVKIAPGGMGSFHAMINSSVHVIMYL
YYGLSAFGPVAQPYLWWKKHMTAIQLIQFVLVSLHISQYYFMSSCNYQYPVIIHLIWMYG
TIFFMLFSNFWYHSYTKGKRLPRALQQNGAPGIAKVKAN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50596155
n/a
NameBDBM50596155
Synonyms:CHEMBL5174762
TypeSmall organic molecule
Emp. Form.C18H15FN4O
Mol. Mass.322.3363
SMILESFc1ccccc1C1(CC1)C(=O)Nc1ccn(n1)-c1ccncc1
Structure
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