| Reaction Details |
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 | Report a problem with these data |
| Target | Bone morphogenetic protein receptor type-1A |
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| Ligand | BDBM50596222 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2219791 (CHEMBL5133125) |
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| IC50 | 129±n/a nM |
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| Citation |  Witten, MR; Wu, L; Lai, CT; Kapilashrami, K; Pusey, M; Gallagher, K; Chen, Y; Yao, W Inhibition of ALK2 with bicyclic pyridyllactams. Bioorg Med Chem Lett55:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bone morphogenetic protein receptor type-1A |
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| Name: | Bone morphogenetic protein receptor type-1A |
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| Synonyms: | ACVRLK3 | ALK3 | Activin receptor-like kinase 3 (ALK-3) | BMPR1A | BMR1A_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 60204.46 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P36894 |
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| Residue: | 532 |
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| Sequence: | MPQLYIYIRLLGAYLFIISRVQGQNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLK
CYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRR
TIECCRTNLCNQYLQPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYC
KSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQV
GKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTG
SWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAH
RDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKN
HFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLR
PIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI
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| BDBM50596222 |
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| n/a |
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| Name | BDBM50596222 |
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| Synonyms: | CHEMBL5178564 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H32N6O2 |
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| Mol. Mass. | 436.5499 |
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| SMILES | CC(=O)N1CCC(CC1)n1cc(cn1)-c1cnc(N)c2C(=O)N(CCc12)C1CCCCC1 |
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| Structure | 
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