| Reaction Details |
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 | Report a problem with these data |
| Target | Pituitary adenylate cyclase-activating polypeptide type I receptor |
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| Ligand | BDBM50596675 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2221684 (CHEMBL5135018) |
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| IC50 | 1.5±n/a nM |
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| Citation |  Takasaki, I; Watanabe, A; Okada, T; Kanayama, D; Nagashima, R; Shudo, M; Shimodaira, A; Nunomura, K; Lin, B; Watanabe, Y; Gouda, H; Miyata, A; Kurihara, T; Toyooka, N Design and synthesis of pyrido[2,3-d]pyrimidine derivatives for a novel PAC1 receptor antagonist. Eur J Med Chem231:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Pituitary adenylate cyclase-activating polypeptide type I receptor |
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| Name: | Pituitary adenylate cyclase-activating polypeptide type I receptor |
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| Synonyms: | ADCYAP1R1 | PACR_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53307.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_498617 |
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| Residue: | 468 |
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| Sequence: | MAGVVHVSLAALLLLPMAPAMHSDCIFKKEQAMCLEKIQRANELMGFNDSSPGCPGMWDN
ITCWKPAHVGEMVLVSCPELFRIFNPDQVWETETIGESDFGDSNSLDLSDMGVVSRNCTE
DGWSEPFPHYFDACGFDEYESETGDQDYYYLSVKALYTVGYSTSLVTLTTAMVILCRFRK
LHCTRNFIHMNLFVSFMLRAISVFIKDWILYAEQDSNHCFISTVECKAVMVFFHYCVVSN
YFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTPTVCVTVWATLRLYFDDTGCWDMN
DSTALWWVIKGPVVGSIMVNFVLFIGIIVILVQKLQSPDMGGNESSIYLRLARSTLLLIP
LFGIHYTVFAFSPENVSKRERLVFELGLGSFQGFVVAVLYCFLNGEVQAEIKRKWRSWKV
NRYFAVDFKHRHPSLASSGVNGGTQLSILSKSSSQIRMSGLPADNLAT
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| BDBM50596675 |
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| n/a |
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| Name | BDBM50596675 |
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| Synonyms: | CHEMBL5208587 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H18N4O4 |
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| Mol. Mass. | 342.3492 |
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| SMILES | COc1cc(ccc1OCC=C)C1CC(=O)Nc2nc(N)[nH]c(=O)c12 |
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| Structure | 
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