Ki Summary

Reaction Details

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Target

Melanocortin receptor 4

Ligand

BDBM50174075

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_321454 (CHEMBL879484)

EC50

130±n/a nM

Citation

Chu, XJ; Bartkovitz, D; Danho, W; Swistok, J; Cheung, AW; Kurylko, G; Rowan, K; Yeon, M; Franco, L; Qi, L; Chen, L; Yagaloff, K Discovery of 1-amino-4-phenylcyclohexane-1-carboxylic acid and its influence on agonist selectivity between human melanocortin-4 and -1 receptors in linear pentapeptides. Bioorg Med Chem Lett15:4910-4 (2005) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Melanocortin receptor 4

Name:

Melanocortin receptor 4

Synonyms:

Type:

Enzyme

Mol. Mass.:

36949.50

Organism:

Homo sapiens (Human)

Description:

P32245

Residue:

332

Sequence:

MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY

BDBM50174075

n/a

Name

BDBM50174075

Synonyms:

1-Pentanoylamino-4-phenyl-cyclohexanecarboxylic acid ((R)-1-{(S)-1-[(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethylcarbamoyl]-4-guanidino-butylcarbamoyl}-2-phenyl-ethyl)-amide | CHEMBL199037 | Penta-Apc-DPhe-Arg-Trp-NH2

Type

Small organic molecule

Emp. Form.

C44H57N9O5

Mol. Mass.

791.9807

SMILES

CCCCC(=O)N[C@@]1(CC[C@@H](CC1)c1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O |wU:44.46,7.6,10.13,wD:7.20,22.23,33.35,(-8.92,-.75,;-7.61,-1.51,;-6.29,-.76,;-4.97,-1.52,;-3.64,-.76,;-3.64,.77,;-2.32,-1.53,;-1.94,-3,;-3.32,-2.38,;-4.53,-3.28,;-4.38,-4.78,;-2.99,-5.4,;-1.77,-4.5,;-5.6,-5.66,;-6.97,-5.04,;-8.2,-5.95,;-8.05,-7.44,;-6.65,-8.06,;-5.45,-7.16,;-.71,-2.1,;-.88,-.59,;.67,-2.71,;1.89,-1.82,;1.89,-.26,;2.3,1.26,;1.17,2.35,;1.56,3.87,;3.07,4.3,;4.19,3.19,;3.8,1.68,;3.18,-2.68,;3.18,-4.24,;4.53,-1.94,;5.77,-2.85,;5.77,-4.4,;7.11,-5.17,;7.11,-6.72,;8.44,-7.44,;9.79,-8.27,;9.79,-9.82,;11.13,-7.49,;7.05,-1.97,;7.06,-.42,;8.42,-2.71,;9.64,-1.82,;9.64,-.26,;10.15,1.21,;11.63,1.67,;11.65,3.22,;10.2,3.72,;9.58,5.14,;8.05,5.33,;7.12,4.1,;7.72,2.68,;9.27,2.48,;10.93,-2.68,;12.3,-1.94,;10.95,-4.24,)|

Structure