| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Nicotinamide N-methyltransferase |
|---|
| Ligand | BDBM50598878 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2228242 (CHEMBL5141755) |
|---|
| IC50 | 100±n/a nM |
|---|
| Citation |  Yoshida, S; Uehara, S; Kondo, N; Takahashi, Y; Yamamoto, S; Kameda, A; Kawagoe, S; Inoue, N; Yamada, M; Yoshimura, N; Tachibana, Y Peptide-to-Small Molecule: A Pharmacophore-Guided Small Molecule Lead Generation Strategy from High-Affinity Macrocyclic Peptides. J Med Chem65:10655-10673 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Nicotinamide N-methyltransferase |
|---|
| Name: | Nicotinamide N-methyltransferase |
|---|
| Synonyms: | NNMT | NNMT_HUMAN | Nicotinamide N-methyltransferase | Nicotinamide N-methyltransferase (NNMT) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 29571.16 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 264 |
|---|
| Sequence: | MESGFTSKDTYLSHFNPRDYLEKYYKFGSRHSAESQILKHLLKNLFKIFCLDGVKGDLLI
DIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKKEPEAFDWSPVVTYVCDLEGN
RVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRAL
RNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQ
SYSSTMANNEGLFSLVARKLSRPL
|
|
|
|---|
| BDBM50598878 |
|---|
| n/a |
|---|
| Name | BDBM50598878 |
|---|
| Synonyms: | CHEMBL5174146 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C58H77N15O11S |
|---|
| Mol. Mass. | 1192.391 |
|---|
| SMILES | [H][C@@]12CCCN1C(=O)[C@H](Cc1c[nH]c3ccccc13)NC(=O)CN(CCCCCC)C(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccc(cc1)C(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)CSC[C@H](NC2=O)C(=O)NCC(N)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
