| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Prostaglandin G/H synthase 1 |
|---|
| Ligand | BDBM50176532 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_327426 (CHEMBL863476) |
|---|
| IC50 | 4000±n/a nM |
|---|
| Citation |  Sakya, SM; DeMello, KM; Minich, ML; Rast, B; Shavnya, A; Rafka, RJ; Koss, DA; Cheng, H; Li, J; Jaynes, BH; Ziegler, CB; Mann, DW; Petras, CF; Seibel, SB; Silvia, AM; George, DM; Lund, LA; St Denis, S; Hickman, A; Haven, ML; Lynch, MP 5-heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part 1: Structure-activity relationship studies of 5-alkylamino pyrazoles and discovery of a potent, selective, and orally active analog. Bioorg Med Chem Lett16:288-92 (2005) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Prostaglandin G/H synthase 1 |
|---|
| Name: | Prostaglandin G/H synthase 1 |
|---|
| Synonyms: | COX1 | Cyclooxygenase-1 | PGH synthase 1 | PGH1_CANLF | PGHS-1 | PHS 1 | PTGS1 | Prostaglandin G/H synthase 1 | Prostaglandin H2 synthase 1 | Prostaglandin-endoperoxide synthase 1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 69314.28 |
|---|
| Organism: | Canis familiaris |
|---|
| Description: | ChEMBL_327426 |
|---|
| Residue: | 603 |
|---|
| Sequence: | MSRGSRLHRWPLLLLLLLLLPPPPVLPAEARTPAPVNPCCYYPCQHQGICVRFGLDRYQC
DCTRTGYSGPNCTIPELWTWLRNSLRPSPSFLHFLLTHGRWFWEFINATFIRDMLMRLVL
TARSNLIPSPPTYNIAHDYISWESFSNVSYYTRVLPSVPQDCPTPMGTKGKKQLPDAQLL
GRRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDN
LDRQYQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGILPQSQMAVGQEVFGLLPG
LMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTARLILIGETIKIVIEEYVQQLSGYFL
QLKFDPELLFSAQFQYRNRIAMEFNQLYHWHPLMPDSFWVGSQEYSYEQFLFNTSMLTHY
GIEALVDAFSRQSAGRIGGGRNIDHHVLHVAVETIKESRELRLQPFNEYRKRFGMRPYMS
FQELTGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGN
PICSPEYWKPSTFGGEMGFNMVKTATLKKLVCLNTKTCPYVSFRVPDPHQDGGPGVERPS
TEL
|
|
|
|---|
| BDBM50176532 |
|---|
| n/a |
|---|
| Name | BDBM50176532 |
|---|
| Synonyms: | 6-(4-cyano-3-(difluoromethyl)-5-(2-methylbutylamino)-1H-pyrazol-1-yl)pyridine-3-sulfonamide | CHEMBL197869 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H18F2N6O2S |
|---|
| Mol. Mass. | 384.404 |
|---|
| SMILES | CCC(C)CNc1c(C#N)c(nn1-c1ccc(cn1)S(N)(=O)=O)C(F)F |
|---|
| Structure | 
|
|---|
Search and Browse
