| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cathepsin K |
|---|
| Ligand | BDBM50177522 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_334148 (CHEMBL868299) |
|---|
| IC50 | 470±n/a nM |
|---|
| Citation |  Adkison, KK; Barrett, DG; Deaton, DN; Gampe, RT; Hassell, AM; Long, ST; McFadyen, RB; Miller, AB; Miller, LR; Payne, JA; Shewchuk, LM; Wells-Knecht, KJ; Willard, DH; Wright, LL Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors? Bioorg Med Chem Lett16:978-83 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cathepsin K |
|---|
| Name: | Cathepsin K |
|---|
| Synonyms: | CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 36975.68 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P43235 |
|---|
| Residue: | 329 |
|---|
| Sequence: | MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
|
|
|
|---|
| BDBM50177522 |
|---|
| n/a |
|---|
| Name | BDBM50177522 |
|---|
| Synonyms: | CHEMBL204305 | {(S)-1-[(4,5-dihydro-thiazol-3-yl)-hydrazonomethyl]-pentyl}-carbamic acid tert-butyl ester |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H27N4O2S |
|---|
| Mol. Mass. | 315.454 |
|---|
| SMILES | CCCC[C@H](NC(=O)OC(C)(C)C)C=NN[N+]1=CSCC1 |w:14.14,t:16| |
|---|
| Structure | 
|
|---|
Search and Browse
