| Reaction Details |
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 | Report a problem with these data |
| Target | Polyprenyl synthetase family protein |
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| Ligand | BDBM50180148 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_330072 (CHEMBL858875) |
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| IC50 | 28600±n/a nM |
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| Citation |  Hudock, MP; Sanz-Rodríguez, CE; Song, Y; Chan, JM; Zhang, Y; Odeh, S; Kosztowski, T; Leon-Rossell, A; Concepción, JL; Yardley, V; Croft, SL; Urbina, JA; Oldfield, E Inhibition of Trypanosoma cruzi hexokinase by bisphosphonates. J Med Chem49:215-23 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polyprenyl synthetase family protein |
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| Name: | Polyprenyl synthetase family protein |
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| Synonyms: | Farnesyl diphosphate synthase | Farnesyl pyrophosphate synthase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41078.35 |
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| Organism: | Plasmodium falciparum (isolate 3D7) |
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| Description: | ChEMBL_330072 |
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| Residue: | 362 |
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| Sequence: | MAHMERFQKVYEEVQEFLLGDAEKRFEMDVHRKGYLKSMMDTTCLGGKYNRGLCVVDVAE
AMAKDTKMDAAAMERVLHDACVCGWMIEMLQAHFLVEDDIMDHSKTRRGKPCWYLHPGVT
TQVAINDGLILLAWATQMALHYFADRPFLAEVLRVFHDVDLTTTIGQLYDVTSMVDSAKL
DANVAHANTTDYIEYTPFNHRRIVVYKTAYYTYWLPLVMGLLVSGTVEKVDKEATHKVAM
VMGEYFQVQDDVMDCFTPPEKLGKIGTDIEDAKCSWLAVTFLTTAPAEKVAEFKANYGST
DPAKVAVIKQLYTEQNLLARFEEYEKAVVAEIEQLIAALEAQNTAFAASVKVLWSKTYKR
QK
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| BDBM50180148 |
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| n/a |
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| Name | BDBM50180148 |
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| Synonyms: | CHEMBL202878 | [4-fluoro-3-phenylphenylamino]methylenebiphosphonic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C13H14FNO6P2 |
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| Mol. Mass. | 361.1993 |
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| SMILES | OP(O)(=O)C(Nc1ccc(F)c(c1)-c1ccccc1)P(O)(O)=O |
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| Structure | 
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