| Reaction Details |
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 | Report a problem with these data |
| Target | Interleukin-1 receptor-associated kinase 1 |
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| Ligand | BDBM50601440 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2236949 (CHEMBL5150845) |
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| IC50 | 23±n/a nM |
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| Citation |  Wang, Z; Cai, J; Cheng, J; Yang, W; Zhu, Y; Li, H; Lu, T; Chen, Y; Lu, S FLT3 Inhibitors in Acute Myeloid Leukemia: Challenges and Recent Developments in Overcoming Resistance. J Med Chem64:2878-2900 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Interleukin-1 receptor-associated kinase 1 |
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| Name: | Interleukin-1 receptor-associated kinase 1 |
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| Synonyms: | IRAK | IRAK-1 | IRAK1 | IRAK1_HUMAN | Interleukin-1 receptor-associated kinase 1 (IRAK-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 76536.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51617 |
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| Residue: | 712 |
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| Sequence: | MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCE
RSGQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSS
IPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTK
PGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKR
LKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRL
HCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFG
LARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAG
QRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDP
RPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYERLEKLQAVVAGVPGHSEAASCIPP
SPQENSYVSSTGRAHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALR
SWHLTPSCPLDPAPLREAGCPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQI
IINPARQKMVQKLALYEDGALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS
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| BDBM50601440 |
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| n/a |
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| Name | BDBM50601440 |
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| Synonyms: | CHEMBL5176837 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23N7O |
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| Mol. Mass. | 389.4536 |
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| SMILES | COc1cc2ncc(-c3cccc(NC4CCNC4)n3)n2cc1-c1cnn(C)c1 |
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| Structure | 
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