| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Coagulation factor IX |
|---|
| Ligand | BDBM14143 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_350918 (CHEMBL869020) |
|---|
| Ki | 99±n/a nM |
|---|
| Citation |  Vijaykumar, D; Sprengeler, PA; Shaghafi, M; Spencer, JR; Katz, BA; Yu, C; Rai, R; Young, WB; Schultz, B; Janc, J Discovery of novel hydroxy pyrazole based factor IXa inhibitor. Bioorg Med Chem Lett16:2796-9 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Coagulation factor IX |
|---|
| Name: | Coagulation factor IX |
|---|
| Synonyms: | Christmas factor | Coagulation factor IX precursor | Coagulation factor IX/VIII | Coagulation factor IXa | Coagulation factor IXa heavy chain | Coagulation factor IXa light chain | F9 | FA9_HUMAN | Factor IX | Factor IXa | Factor IXa (fIXa) | PTC | Plasma thromboplastin component |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 51768.83 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P00740 |
|---|
| Residue: | 461 |
|---|
| Sequence: | MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL
ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCP
FGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGR
VSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPW
QVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRII
PHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVF
HKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVE
GTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
|
|
|
|---|
| BDBM14143 |
|---|
| n/a |
|---|
| Name | BDBM14143 |
|---|
| Synonyms: | 2-(2-HYDROXY-BIPHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE | 2-(2-hydroxy-3-phenylphenyl)-1H-1,3-benzodiazole-5-carboximidamide | APC-7806 | CHEMBL327715 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H16N4O |
|---|
| Mol. Mass. | 328.3672 |
|---|
| SMILES | NC(=N)c1ccc2nc([nH]c2c1)-c1cccc(-c2ccccc2)c1O |
|---|
| Structure | 
|
|---|
Search and Browse
