| Reaction Details |
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 | Report a problem with these data |
| Target | Bromodomain-containing protein 3 |
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| Ligand | BDBM50602884 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2242380 (CHEMBL5156590) |
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| Kd | 1500±n/a nM |
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| Citation |  Xiang, Q; Wang, C; Wu, T; Zhang, C; Hu, Q; Luo, G; Hu, J; Zhuang, X; Zou, L; Shen, H; Wu, X; Zhang, Y; Kong, X; Liu, J; Xu, Y Design, Synthesis, and Biological Evaluation of 1-(Indolizin-3-yl)ethan-1-ones as CBP Bromodomain Inhibitors for the Treatment of Prostate Cancer. J Med Chem65:785-810 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bromodomain-containing protein 3 |
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| Name: | Bromodomain-containing protein 3 |
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| Synonyms: | BRD3 | BRD3_HUMAN | Bromodomain and extra-terminal motif (BET) | Bromodomain-containing protein 3 | Bromodomain-containing protein 3 (BRD3) | KIAA0043 | RING3-like protein | RING3L |
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| Type: | Protein |
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| Mol. Mass.: | 79571.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q15059 |
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| Residue: | 726 |
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| Sequence: | MSTATTVAPAGIPATPGPVNPPPPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFY
QPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTD
DIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRKPAAGAQSAGTQQVAAVSSVSPA
TPFQSVPPTVSQTPVIAATPVPTITANVTSVPVPPAAAPPPPATPIVPVVPPTPPVVKKK
GVKRKADTTTPTTSAITASRSESPPPLSDPKQAKVVARRESGGRPIKPPKKDLEDGEVPQ
HAGKKGKLSEHLRYCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLST
VKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPV
EAPALPAPAAPMVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAAL
SQAPVNKPKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPPAKQAQQKKAPAKKA
NSTTTAGRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQ
SREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSKEEL
AQEKKKELEKRLQDVSGQLSSSKKPARKEKPGSAPSGGPSRLSSSSSSESGSSSSSGSSS
DSSDSE
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| BDBM50602884 |
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| n/a |
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| Name | BDBM50602884 |
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| Synonyms: | CHEMBL5179520 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H25FN4O4 |
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| Mol. Mass. | 476.4995 |
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| SMILES | COc1ccn2c(cc(C(=O)Nc3cc(cc(-c4cnn(c4)C4CC4)c3F)C(C)O)c2c1)C(C)=O |
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| Structure | 
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