Reaction Details |
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Target | Microsomal triglyceride transfer protein large subunit |
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Ligand | BDBM50184162 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_364710 (CHEMBL866306) |
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IC50 | 17.38±n/a nM |
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Citation | Li, J; Bertinato, P; Cheng, H; Cole, BM; Bronk, BS; Jaynes, BH; Hickman, A; Haven, ML; Kolosko, NL; Barry, CJ; Manion, TB Discovery of potent and orally active MTP inhibitors as potential anti-obesity agents. Bioorg Med Chem Lett16:3039-42 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Microsomal triglyceride transfer protein large subunit |
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Name: | Microsomal triglyceride transfer protein large subunit |
Synonyms: | MTP | MTP_HUMAN | MTTP | Microsomal triglyceride transfer protein | Microsomal triglyceride transfer protein large subunit |
Type: | PROTEIN |
Mol. Mass.: | 99365.65 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_971724 |
Residue: | 894 |
Sequence: | MILLAVLFLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVLLDRGKGKLQDSVGYRIS
SNVDVALLWRNPDGDDDQLIQITMKDVNVENVNQQRGEKSIFKGKSPSKIMGKENLEALQ
RPTLLHLIHGKVKEFYSYQNEAVAIENIKRGLASLFQTQLSSGTTNEVDISGNCKVTYQA
HQDKVIKIKALDSCKIARSGFTTPNQVLGVSSKATSVTTYKIEDSFVIAVLAEETHNFGL
NFLQTIKGKIVSKQKLELKTTEAGPRLMSGKQAAAIIKAVDSKYTAIPIVGQVFQSHCKG
CPSLSELWRSTRKYLQPDNLSKAEAVRNFLAFIQHLRTAKKEEILQILKMENKEVLPQLV
DAVTSAQTSDSLEAILDFLDFKSDSSIILQERFLYACGFASHPNEELLRALISKFKGSIG
SSDIRETVMIITGTLVRKLCQNEGCKLKAVVEAKKLILGGLEKAEKKEDTRMYLLALKNA
LLPEGIPSLLKYAEAGEGPISHLATTALQRYDLPFITDEVKKTLNRIYHQNRKVHEKTVR
TAAAAIILNNNPSYMDVKNILLSIGELPQEMNKYMLAIVQDILRFEMPASKIVRRVLKEM
VAHNYDRFSRSGSSSAYTGYIERSPRSASTYSLDILYSGSGILRRSNLNIFQYIGKAGLH
GSQVVIEAQGLEALIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSA
SGDPISVVKGLILLIDHSQELQLQSGLKANIEVQGGLAIDISGAMEFSLWYRESKTRVKN
RVTVVITTDITVDSSFVKAGLETSTETEAGLEFISTVQFSQYPFLVCMQMDKDEAPFRQF
EKKYERLSTGRGYVSQKRKESVLAGCEFPLHQENSEMCKVVFAPQPDSTSSGWF
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BDBM50184162 |
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n/a |
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Name | BDBM50184162 |
Synonyms: | CHEMBL379843 | N-((S)-2-oxo-1-phenyl-2-pyrrolidin-1-yl-ethyl)-6-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-nicotinamide |
Type | Small organic molecule |
Emp. Form. | C32H27F3N4O3 |
Mol. Mass. | 572.577 |
SMILES | FC(F)(F)c1ccc(cc1)-c1ccccc1C(=O)Nc1ccc(cn1)C(=O)N[C@H](C(=O)N1CCCC1)c1ccccc1 |
Structure |
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