Found 189 hits with Last Name = 'kolosko' and Initial = 'nl' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184105
(4'-trifluoromethyl-biphenyl-2-carboxylic acid (4-{...)Show SMILES COc1cc(NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)ccc1C(=O)N[C@H](C(=O)NCC1CC1)c1ccccc1 Show InChI InChI=1S/C34H30F3N3O4/c1-44-29-19-25(39-31(41)27-10-6-5-9-26(27)22-13-15-24(16-14-22)34(35,36)37)17-18-28(29)32(42)40-30(23-7-3-2-4-8-23)33(43)38-20-21-11-12-21/h2-10,13-19,21,30H,11-12,20H2,1H3,(H,38,43)(H,39,41)(H,40,42)/t30-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.01 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184109
(4'-trifluoromethyl-biphenyl-2-carboxylic acid {2-m...)Show SMILES CCCNC(=O)[C@@H](NC(=O)c1ccc(NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)c(C)c1)c1ccccc1 Show InChI InChI=1S/C33H30F3N3O3/c1-3-19-37-32(42)29(23-9-5-4-6-10-23)39-30(40)24-15-18-28(21(2)20-24)38-31(41)27-12-8-7-11-26(27)22-13-16-25(17-14-22)33(34,35)36/h4-18,20,29H,3,19H2,1-2H3,(H,37,42)(H,38,41)(H,39,40)/t29-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.64 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184153
(4'-trifluoromethyl-biphenyl-2-carboxylic acid (4-{...)Show SMILES COc1cc(ccc1NC(=O)c1ccccc1-c1ccc(cc1)C(F)(F)F)C(=O)N[C@H](C(=O)NCC1CC1)c1ccccc1 Show InChI InChI=1S/C34H30F3N3O4/c1-44-29-19-24(31(41)40-30(23-7-3-2-4-8-23)33(43)38-20-21-11-12-21)15-18-28(29)39-32(42)27-10-6-5-9-26(27)22-13-16-25(17-14-22)34(35,36)37/h2-10,13-19,21,30H,11-12,20H2,1H3,(H,38,43)(H,39,42)(H,40,41)/t30-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.68 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184111
(4'-trifluoromethyl-biphenyl-2-carboxylic acid [2-m...)Show SMILES COc1cc(ccc1NC(=O)c1ccccc1-c1ccc(cc1)C(F)(F)F)C(=O)N[C@H](C(=O)N1CCCC1)c1ccccc1 Show InChI InChI=1S/C34H30F3N3O4/c1-44-29-21-24(31(41)39-30(23-9-3-2-4-10-23)33(43)40-19-7-8-20-40)15-18-28(29)38-32(42)27-12-6-5-11-26(27)22-13-16-25(17-14-22)34(35,36)37/h2-6,9-18,21,30H,7-8,19-20H2,1H3,(H,38,42)(H,39,41)/t30-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.75 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184165
(4'-trifluoromethyl-biphenyl-2-carboxylic acid (4-{...)Show SMILES Cc1cc(ccc1NC(=O)c1ccccc1-c1ccc(cc1)C(F)(F)F)C(=O)N[C@H](C(=O)NCC1CC1)c1ccccc1 Show InChI InChI=1S/C34H30F3N3O3/c1-21-19-25(31(41)40-30(24-7-3-2-4-8-24)33(43)38-20-22-11-12-22)15-18-29(21)39-32(42)28-10-6-5-9-27(28)23-13-16-26(17-14-23)34(35,36)37/h2-10,13-19,22,30H,11-12,20H2,1H3,(H,38,43)(H,39,42)(H,40,41)/t30-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.78 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184118
(4'-trifluoromethyl-biphenyl-2-carboxylic acid {2-m...)Show SMILES CCCNC(=O)[C@@H](NC(=O)c1ccc(NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)c(OC)c1)c1ccccc1 Show InChI InChI=1S/C33H30F3N3O4/c1-3-19-37-32(42)29(22-9-5-4-6-10-22)39-30(40)23-15-18-27(28(20-23)43-2)38-31(41)26-12-8-7-11-25(26)21-13-16-24(17-14-21)33(34,35)36/h4-18,20,29H,3,19H2,1-2H3,(H,37,42)(H,38,41)(H,39,40)/t29-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184137
(4'-trifluoromethyl-biphenyl-2-carboxylic acid (4-{...)Show SMILES CCCN(CC)C(=O)[C@@H](NC(=O)c1ccc(NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)c(OC)c1)c1ccccc1 Show InChI InChI=1S/C35H34F3N3O4/c1-4-21-41(5-2)34(44)31(24-11-7-6-8-12-24)40-32(42)25-17-20-29(30(22-25)45-3)39-33(43)28-14-10-9-13-27(28)23-15-18-26(19-16-23)35(36,37)38/h6-20,22,31H,4-5,21H2,1-3H3,(H,39,43)(H,40,42)/t31-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.34 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184127
(CHEMBL207443 | N-((S)-Phenyl-propylcarbamoyl-methy...)Show SMILES CCCNC(=O)[C@@H](NC(=O)c1ccc(NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)nc1)c1ccccc1 Show InChI InChI=1S/C31H27F3N4O3/c1-2-18-35-30(41)27(21-8-4-3-5-9-21)38-28(39)22-14-17-26(36-19-22)37-29(40)25-11-7-6-10-24(25)20-12-15-23(16-13-20)31(32,33)34/h3-17,19,27H,2,18H2,1H3,(H,35,41)(H,38,39)(H,36,37,40)/t27-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.53 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50204367
(CHEMBL410414 | dirlotapide)Show SMILES CN(Cc1ccccc1)C(=O)[C@@H](NC(=O)c1cc2cc(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)ccc2n1C)c1ccccc1 |r| Show InChI InChI=1S/C40H33F3N4O3/c1-46(25-26-11-5-3-6-12-26)39(50)36(28-13-7-4-8-14-28)45-38(49)35-24-29-23-31(21-22-34(29)47(35)2)44-37(48)33-16-10-9-15-32(33)27-17-19-30(20-18-27)40(41,42)43/h3-24,36H,25H2,1-2H3,(H,44,48)(H,45,49)/t36-/m0/s1 | PDB
Reactome pathway
KEGG
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| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP assessed as inhibition of apoB secretion from human HepG2 cells |
Bioorg Med Chem Lett 17: 1996-9 (2007)
Article DOI: 10.1016/j.bmcl.2007.01.018
BindingDB Entry DOI: 10.7270/Q2QC034Z |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184152
(4'-trifluoromethyl-biphenyl-2-carboxylic acid 4-[(...)Show SMILES FC(F)(F)c1ccc(cc1)-c1ccccc1C(=O)NCc1ccc(cc1)C(=O)N[C@H](C(=O)NCc1ccccc1)c1ccccc1 Show InChI InChI=1S/C37H30F3N3O3/c38-37(39,40)30-21-19-27(20-22-30)31-13-7-8-14-32(31)35(45)41-24-26-15-17-29(18-16-26)34(44)43-33(28-11-5-2-6-12-28)36(46)42-23-25-9-3-1-4-10-25/h1-22,33H,23-24H2,(H,41,45)(H,42,46)(H,43,44)/t33-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.97 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184138
(4'-trifluoromethyl-biphenyl-2-carboxylic acid [2-m...)Show SMILES Cc1cc(ccc1NC(=O)c1ccccc1-c1ccc(cc1)C(F)(F)F)C(=O)N[C@H](C(=O)N1CCCC1)c1ccccc1 Show InChI InChI=1S/C34H30F3N3O3/c1-22-21-25(31(41)39-30(24-9-3-2-4-10-24)33(43)40-19-7-8-20-40)15-18-29(22)38-32(42)28-12-6-5-11-27(28)23-13-16-26(17-14-23)34(35,36)37/h2-6,9-18,21,30H,7-8,19-20H2,1H3,(H,38,42)(H,39,41)/t30-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.37 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184147
(4'-trifluoromethyl-biphenyl-2-carboxylic acid {4-[...)Show SMILES Cc1cc(ccc1NC(=O)c1ccccc1-c1ccc(cc1)C(F)(F)F)C(=O)N[C@H](C(=O)NCc1ccccc1)c1ccccc1 Show InChI InChI=1S/C37H30F3N3O3/c1-24-22-28(34(44)43-33(27-12-6-3-7-13-27)36(46)41-23-25-10-4-2-5-11-25)18-21-32(24)42-35(45)31-15-9-8-14-30(31)26-16-19-29(20-17-26)37(38,39)40/h2-22,33H,23H2,1H3,(H,41,46)(H,42,45)(H,43,44)/t33-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184104
(4'-trifluoromethyl-biphenyl-2-carboxylic acid {4-[...)Show SMILES COc1cc(ccc1NC(=O)c1ccccc1-c1ccc(cc1)C(F)(F)F)C(=O)N[C@H](C(=O)NCc1ccccc1)c1ccccc1 Show InChI InChI=1S/C37H30F3N3O4/c1-47-32-22-27(34(44)43-33(26-12-6-3-7-13-26)36(46)41-23-24-10-4-2-5-11-24)18-21-31(32)42-35(45)30-15-9-8-14-29(30)25-16-19-28(20-17-25)37(38,39)40/h2-22,33H,23H2,1H3,(H,41,46)(H,42,45)(H,43,44)/t33-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.85 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184130
(4'-trifluoromethyl-biphenyl-2-carboxylic acid 4-{[...)Show SMILES CN(Cc1ccccc1)C(=O)[C@@H](NC(=O)c1ccc(CNC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)cc1)c1ccccc1 Show InChI InChI=1S/C38H32F3N3O3/c1-44(25-27-10-4-2-5-11-27)37(47)34(29-12-6-3-7-13-29)43-35(45)30-18-16-26(17-19-30)24-42-36(46)33-15-9-8-14-32(33)28-20-22-31(23-21-28)38(39,40)41/h2-23,34H,24-25H2,1H3,(H,42,46)(H,43,45)/t34-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.11 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184139
(4'-trifluoromethyl-biphenyl-2-carboxylic acid (4-{...)Show SMILES CN(Cc1ccccc1)C(=O)[C@@H](NC(=O)c1ccc(NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)c(C)c1)c1ccccc1 Show InChI InChI=1S/C38H32F3N3O3/c1-25-23-29(35(45)43-34(28-13-7-4-8-14-28)37(47)44(2)24-26-11-5-3-6-12-26)19-22-33(25)42-36(46)32-16-10-9-15-31(32)27-17-20-30(21-18-27)38(39,40)41/h3-23,34H,24H2,1-2H3,(H,42,46)(H,43,45)/t34-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.62 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184124
(4'-trifluoromethyl-biphenyl-2-carboxylic acid 4-{[...)Show SMILES CCCN(CC)C(=O)[C@@H](NC(=O)c1ccc(CNC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)cc1)c1ccccc1 Show InChI InChI=1S/C35H34F3N3O3/c1-3-22-41(4-2)34(44)31(26-10-6-5-7-11-26)40-32(42)27-16-14-24(15-17-27)23-39-33(43)30-13-9-8-12-29(30)25-18-20-28(21-19-25)35(36,37)38/h5-21,31H,3-4,22-23H2,1-2H3,(H,39,43)(H,40,42)/t31-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.05 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184141
(4'-trifluoromethyl-biphenyl-2-carboxylic acid (4-{...)Show SMILES CCCN(CC)C(=O)[C@@H](NC(=O)c1ccc(NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)cc1OC)c1ccccc1 Show InChI InChI=1S/C35H34F3N3O4/c1-4-21-41(5-2)34(44)31(24-11-7-6-8-12-24)40-33(43)29-20-19-26(22-30(29)45-3)39-32(42)28-14-10-9-13-27(28)23-15-17-25(18-16-23)35(36,37)38/h6-20,22,31H,4-5,21H2,1-3H3,(H,39,42)(H,40,43)/t31-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.28 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184160
(1-(4'-trifluoromethyl-biphenyl-2-carbonyl)-2,3-dih...)Show SMILES CCCNC(=O)[C@@H](NC(=O)c1ccc2N(CCc2c1)C(=O)c1ccccc1-c1ccc(cc1)C(F)(F)F)c1ccccc1 Show InChI InChI=1S/C34H30F3N3O3/c1-2-19-38-32(42)30(23-8-4-3-5-9-23)39-31(41)25-14-17-29-24(21-25)18-20-40(29)33(43)28-11-7-6-10-27(28)22-12-15-26(16-13-22)34(35,36)37/h3-17,21,30H,2,18-20H2,1H3,(H,38,42)(H,39,41)/t30-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.53 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184166
(4'-trifluoromethyl-biphenyl-2-carboxylic acid 4-((...)Show SMILES FC(F)(F)c1ccc(cc1)-c1ccccc1C(=O)NCc1ccc(cc1)C(=O)N[C@H](C(=O)N1CCCCC1)c1ccccc1 Show InChI InChI=1S/C35H32F3N3O3/c36-35(37,38)28-19-17-25(18-20-28)29-11-5-6-12-30(29)33(43)39-23-24-13-15-27(16-14-24)32(42)40-31(26-9-3-1-4-10-26)34(44)41-21-7-2-8-22-41/h1,3-6,9-20,31H,2,7-8,21-23H2,(H,39,43)(H,40,42)/t31-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.67 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184112
(4'-trifluoromethyl-biphenyl-2-carboxylic acid [3-m...)Show SMILES COc1cc(NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)ccc1C(=O)N[C@H](C(=O)N1CCCCC1)c1ccccc1 Show InChI InChI=1S/C35H32F3N3O4/c1-45-30-22-26(39-32(42)28-13-7-6-12-27(28)23-14-16-25(17-15-23)35(36,37)38)18-19-29(30)33(43)40-31(24-10-4-2-5-11-24)34(44)41-20-8-3-9-21-41/h2,4-7,10-19,22,31H,3,8-9,20-21H2,1H3,(H,39,42)(H,40,43)/t31-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.23 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184100
(4'-trifluoromethyl-biphenyl-2-carboxylic acid [2-m...)Show SMILES COc1cc(ccc1NC(=O)c1ccccc1-c1ccc(cc1)C(F)(F)F)C(=O)N[C@H](C(=O)N1CCCCC1)c1ccccc1 Show InChI InChI=1S/C35H32F3N3O4/c1-45-30-22-25(32(42)40-31(24-10-4-2-5-11-24)34(44)41-20-8-3-9-21-41)16-19-29(30)39-33(43)28-13-7-6-12-27(28)23-14-17-26(18-15-23)35(36,37)38/h2,4-7,10-19,22,31H,3,8-9,20-21H2,1H3,(H,39,43)(H,40,42)/t31-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.38 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184148
(4'-trifluoromethyl-biphenyl-2-carboxylic acid [3-m...)Show SMILES COc1cc(NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)ccc1C(=O)N[C@H](C(=O)N1CCCC1)c1ccccc1 Show InChI InChI=1S/C34H30F3N3O4/c1-44-29-21-25(38-31(41)27-12-6-5-11-26(27)22-13-15-24(16-14-22)34(35,36)37)17-18-28(29)32(42)39-30(23-9-3-2-4-10-23)33(43)40-19-7-8-20-40/h2-6,9-18,21,30H,7-8,19-20H2,1H3,(H,38,41)(H,39,42)/t30-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.47 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184110
(4'-trifluoromethyl-biphenyl-2-carboxylic acid (4-{...)Show SMILES COc1cc(ccc1NC(=O)c1ccccc1-c1ccc(cc1)C(F)(F)F)C(=O)N[C@H](C(=O)N(C)Cc1ccccc1)c1ccccc1 Show InChI InChI=1S/C38H32F3N3O4/c1-44(24-25-11-5-3-6-12-25)37(47)34(27-13-7-4-8-14-27)43-35(45)28-19-22-32(33(23-28)48-2)42-36(46)31-16-10-9-15-30(31)26-17-20-29(21-18-26)38(39,40)41/h3-23,34H,24H2,1-2H3,(H,42,46)(H,43,45)/t34-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.14 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184123
(4'-trifluoromethyl-biphenyl-2-carboxylic acid [4-(...)Show SMILES CN(Cc1ccccc1)C(=O)[C@@H](NC(=O)CSc1ccc(NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)cc1)c1ccccc1 Show InChI InChI=1S/C38H32F3N3O3S/c1-44(24-26-10-4-2-5-11-26)37(47)35(28-12-6-3-7-13-28)43-34(45)25-48-31-22-20-30(21-23-31)42-36(46)33-15-9-8-14-32(33)27-16-18-29(19-17-27)38(39,40)41/h2-23,35H,24-25H2,1H3,(H,42,46)(H,43,45)/t35-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.33 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184129
(4'-trifluoromethyl-biphenyl-2-carboxylic acid 4-((...)Show SMILES FC(F)(F)c1ccc(cc1)-c1ccccc1C(=O)NCc1ccc(cc1)C(=O)N[C@H](C(=O)N1CCCC1)c1ccccc1 Show InChI InChI=1S/C34H30F3N3O3/c35-34(36,37)27-18-16-24(17-19-27)28-10-4-5-11-29(28)32(42)38-22-23-12-14-26(15-13-23)31(41)39-30(25-8-2-1-3-9-25)33(43)40-20-6-7-21-40/h1-5,8-19,30H,6-7,20-22H2,(H,38,42)(H,39,41)/t30-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.15 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184120
(4'-trifluoromethyl-biphenyl-2-carboxylic acid {4-[...)Show SMILES FC(F)(F)c1ccc(cc1)-c1ccccc1C(=O)Nc1ccc(SCC(=O)N[C@H](C(=O)N2CCCC2)c2ccccc2)cc1 Show InChI InChI=1S/C34H30F3N3O3S/c35-34(36,37)25-14-12-23(13-15-25)28-10-4-5-11-29(28)32(42)38-26-16-18-27(19-17-26)44-22-30(41)39-31(24-8-2-1-3-9-24)33(43)40-20-6-7-21-40/h1-5,8-19,31H,6-7,20-22H2,(H,38,42)(H,39,41)/t31-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.27 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184125
(1-(4'-trifluoromethyl-biphenyl-2-carbonyl)-piperid...)Show SMILES CCCN(CC)C(=O)[C@@H](NC(=O)C1CCN(CC1)C(=O)c1ccccc1-c1ccc(cc1)C(F)(F)F)c1ccccc1 Show InChI InChI=1S/C33H36F3N3O3/c1-3-20-38(4-2)32(42)29(24-10-6-5-7-11-24)37-30(40)25-18-21-39(22-19-25)31(41)28-13-9-8-12-27(28)23-14-16-26(17-15-23)33(34,35)36/h5-17,25,29H,3-4,18-22H2,1-2H3,(H,37,40)/t29-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.43 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50182352
(2-(5-(3-chloro-4-(furan-2-yl)phenyl)-3-(difluorome...)Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(-c2ccco2)c(Cl)c1)C(F)F Show InChI InChI=1S/C20H14ClF2N3O3S/c1-30(27,28)13-5-7-19(24-11-13)26-17(10-16(25-26)20(22)23)12-4-6-14(15(21)9-12)18-3-2-8-29-18/h2-11,20H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Veterinary Medicine Research and Development Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of COX2 in canine whole blood |
Bioorg Med Chem Lett 16: 2076-80 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.059
BindingDB Entry DOI: 10.7270/Q28K78PW |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50182338
(2-(5-(4-(furan-2-yl)-3-methylphenyl)-3-(trifluorom...)Show SMILES Cc1cc(ccc1-c1ccco1)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F Show InChI InChI=1S/C21H16F3N3O3S/c1-13-10-14(5-7-16(13)18-4-3-9-30-18)17-11-19(21(22,23)24)26-27(17)20-8-6-15(12-25-20)31(2,28)29/h3-12H,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Veterinary Medicine Research and Development Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of COX2 in canine whole blood |
Bioorg Med Chem Lett 16: 2076-80 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.059
BindingDB Entry DOI: 10.7270/Q28K78PW |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184102
(4'-trifluoromethyl-biphenyl-2-carboxylic acid 4-((...)Show SMILES FC(F)(F)c1ccc(cc1)-c1ccccc1C(=O)NCc1ccc(cc1)C(=O)N[C@H](C(=O)N1CCOCC1)c1ccccc1 Show InChI InChI=1S/C34H30F3N3O4/c35-34(36,37)27-16-14-24(15-17-27)28-8-4-5-9-29(28)32(42)38-22-23-10-12-26(13-11-23)31(41)39-30(25-6-2-1-3-7-25)33(43)40-18-20-44-21-19-40/h1-17,30H,18-22H2,(H,38,42)(H,39,41)/t30-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 11.8 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50182347
(2-(5-(3-chloro-4-(furan-2-yl)phenyl)-3-(trifluorom...)Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(-c2ccco2)c(Cl)c1)C(F)(F)F Show InChI InChI=1S/C20H13ClF3N3O3S/c1-31(28,29)13-5-7-19(25-11-13)27-16(10-18(26-27)20(22,23)24)12-4-6-14(15(21)9-12)17-3-2-8-30-17/h2-11H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Veterinary Medicine Research and Development Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of COX2 in canine whole blood |
Bioorg Med Chem Lett 16: 2076-80 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.059
BindingDB Entry DOI: 10.7270/Q28K78PW |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184121
(CHEMBL410089 | N-[(S)-(benzyl-methyl-carbamoyl)-ph...)Show SMILES CN(Cc1ccccc1)C(=O)[C@@H](NC(=O)c1ccc(NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)nc1)c1ccccc1 Show InChI InChI=1S/C36H29F3N4O3/c1-43(23-24-10-4-2-5-11-24)35(46)32(26-12-6-3-7-13-26)42-33(44)27-18-21-31(40-22-27)41-34(45)30-15-9-8-14-29(30)25-16-19-28(20-17-25)36(37,38)39/h2-22,32H,23H2,1H3,(H,42,44)(H,40,41,45)/t32-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 13.0 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50182339
(2-(furan-2-yl)-5-(1-(5-(methylsulfonyl)pyridin-2-y...)Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(-c2ccco2)c(c1)C#N)C(F)(F)F Show InChI InChI=1S/C21H13F3N4O3S/c1-32(29,30)15-5-7-20(26-12-15)28-17(10-19(27-28)21(22,23)24)13-4-6-16(14(9-13)11-25)18-3-2-8-31-18/h2-10,12H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Veterinary Medicine Research and Development Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of COX2 in canine whole blood |
Bioorg Med Chem Lett 16: 2076-80 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.059
BindingDB Entry DOI: 10.7270/Q28K78PW |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184115
(4'-trifluoromethyl-biphenyl-2-carboxylic acid {4-[...)Show SMILES COc1cc(NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)ccc1C(=O)N[C@H](C(=O)NCc1ccccc1)c1ccccc1 Show InChI InChI=1S/C37H30F3N3O4/c1-47-32-22-28(42-34(44)30-15-9-8-14-29(30)25-16-18-27(19-17-25)37(38,39)40)20-21-31(32)35(45)43-33(26-12-6-3-7-13-26)36(46)41-23-24-10-4-2-5-11-24/h2-22,33H,23H2,1H3,(H,41,46)(H,42,44)(H,43,45)/t33-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 13.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184134
(CHEMBL263215 | N-[(S)-(ethyl-propyl-carbamoyl)-phe...)Show SMILES CCCN(CC)C(=O)[C@@H](NC(=O)c1ccc(NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)nc1)c1ccccc1 Show InChI InChI=1S/C33H31F3N4O3/c1-3-20-40(4-2)32(43)29(23-10-6-5-7-11-23)39-30(41)24-16-19-28(37-21-24)38-31(42)27-13-9-8-12-26(27)22-14-17-25(18-15-22)33(34,35)36/h5-19,21,29H,3-4,20H2,1-2H3,(H,39,41)(H,37,38,42)/t29-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 13.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184106
(4'-trifluoromethyl-biphenyl-2-carboxylic acid [3-m...)Show SMILES COc1cc(NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)ccc1C(=O)N[C@H](C(=O)N1CCOCC1)c1ccccc1 Show InChI InChI=1S/C34H30F3N3O5/c1-44-29-21-25(38-31(41)27-10-6-5-9-26(27)22-11-13-24(14-12-22)34(35,36)37)15-16-28(29)32(42)39-30(23-7-3-2-4-8-23)33(43)40-17-19-45-20-18-40/h2-16,21,30H,17-20H2,1H3,(H,38,41)(H,39,42)/t30-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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antibodypedia
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 14.8 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184117
(1-(4'-trifluoromethyl-biphenyl-2-carbonyl)-2,3-dih...)Show SMILES FC(F)(F)c1ccc(cc1)-c1ccccc1C(=O)N1CCc2cc(ccc12)C(=O)N[C@H](C(=O)N1CCCC1)c1ccccc1 Show InChI InChI=1S/C35H30F3N3O3/c36-35(37,38)27-15-12-23(13-16-27)28-10-4-5-11-29(28)33(43)41-21-18-25-22-26(14-17-30(25)41)32(42)39-31(24-8-2-1-3-9-24)34(44)40-19-6-7-20-40/h1-5,8-17,22,31H,6-7,18-21H2,(H,39,42)/t31-/m0/s1 | PDB
Reactome pathway
KEGG
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PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 14.9 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184098
(4'-trifluoromethyl-biphenyl-2-carboxylic acid 4-{[...)Show SMILES CCCCN(C)C(=O)[C@@H](NC(=O)c1ccc(CNC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)cc1)c1ccccc1 Show InChI InChI=1S/C35H34F3N3O3/c1-3-4-22-41(2)34(44)31(26-10-6-5-7-11-26)40-32(42)27-16-14-24(15-17-27)23-39-33(43)30-13-9-8-12-29(30)25-18-20-28(21-19-25)35(36,37)38/h5-21,31H,3-4,22-23H2,1-2H3,(H,39,43)(H,40,42)/t31-/m0/s1 | PDB
Reactome pathway
KEGG
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PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 15.6 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184107
(CHEMBL245300 | N-[(S)-(butyl-methyl-carbamoyl)-phe...)Show SMILES CCCCN(C)C(=O)[C@@H](NC(=O)c1ccc(NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)nc1)c1ccccc1 Show InChI InChI=1S/C33H31F3N4O3/c1-3-4-20-40(2)32(43)29(23-10-6-5-7-11-23)39-30(41)24-16-19-28(37-21-24)38-31(42)27-13-9-8-12-26(27)22-14-17-25(18-15-22)33(34,35)36/h5-19,21,29H,3-4,20H2,1-2H3,(H,39,41)(H,37,38,42)/t29-/m0/s1 | PDB
Reactome pathway
KEGG
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PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 16.9 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184101
(4'-trifluoromethyl-biphenyl-2-carboxylic acid 4-{[...)Show SMILES FC(F)(F)c1ccc(cc1)-c1ccccc1C(=O)NCc1ccc(cc1)C(=O)N[C@H](C(=O)NCC1CC1)c1ccccc1 Show InChI InChI=1S/C34H30F3N3O3/c35-34(36,37)27-18-16-24(17-19-27)28-8-4-5-9-29(28)32(42)38-20-23-12-14-26(15-13-23)31(41)40-30(25-6-2-1-3-7-25)33(43)39-21-22-10-11-22/h1-9,12-19,22,30H,10-11,20-21H2,(H,38,42)(H,39,43)(H,40,41)/t30-/m0/s1 | PDB
Reactome pathway
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PC sid
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| Article
PubMed
| n/a | n/a | 16.9 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184163
(4'-trifluoromethyl-biphenyl-2-carboxylic acid [4-(...)Show SMILES CCCCN(C)C(=O)[C@@H](NC(=O)CSc1ccc(NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)cc1)c1ccccc1 Show InChI InChI=1S/C35H34F3N3O3S/c1-3-4-22-41(2)34(44)32(25-10-6-5-7-11-25)40-31(42)23-45-28-20-18-27(19-21-28)39-33(43)30-13-9-8-12-29(30)24-14-16-26(17-15-24)35(36,37)38/h5-21,32H,3-4,22-23H2,1-2H3,(H,39,43)(H,40,42)/t32-/m0/s1 | PDB
Reactome pathway
KEGG
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antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 17.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184162
(CHEMBL379843 | N-((S)-2-oxo-1-phenyl-2-pyrrolidin-...)Show SMILES FC(F)(F)c1ccc(cc1)-c1ccccc1C(=O)Nc1ccc(cn1)C(=O)N[C@H](C(=O)N1CCCC1)c1ccccc1 Show InChI InChI=1S/C32H27F3N4O3/c33-32(34,35)24-15-12-21(13-16-24)25-10-4-5-11-26(25)30(41)37-27-17-14-23(20-36-27)29(40)38-28(22-8-2-1-3-9-22)31(42)39-18-6-7-19-39/h1-5,8-17,20,28H,6-7,18-19H2,(H,38,40)(H,36,37,41)/t28-/m0/s1 | PDB
Reactome pathway
KEGG
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antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 17.4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184113
(1-(4'-trifluoromethyl-biphenyl-2-carbonyl)-2,3-dih...)Show SMILES CCCN(CC)C(=O)[C@@H](NC(=O)c1ccc2N(CCc2c1)C(=O)c1ccccc1-c1ccc(cc1)C(F)(F)F)c1ccccc1 Show InChI InChI=1S/C36H34F3N3O3/c1-3-21-41(4-2)35(45)32(25-10-6-5-7-11-25)40-33(43)27-16-19-31-26(23-27)20-22-42(31)34(44)30-13-9-8-12-29(30)24-14-17-28(18-15-24)36(37,38)39/h5-19,23,32H,3-4,20-22H2,1-2H3,(H,40,43)/t32-/m0/s1 | PDB
Reactome pathway
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| CHEMBL
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PC sid
UniChem
Patents
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| Article
PubMed
| n/a | n/a | 18.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50182353
(2-(3-(difluoromethyl)-5-(3-methyl-4-(thiazol-4-yl)...)Show SMILES Cc1cc(ccc1-c1cscn1)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)F Show InChI InChI=1S/C20H16F2N4O2S2/c1-12-7-13(3-5-15(12)17-10-29-11-24-17)18-8-16(20(21)22)25-26(18)19-6-4-14(9-23-19)30(2,27)28/h3-11,20H,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Veterinary Medicine Research and Development Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of COX2 in canine whole blood |
Bioorg Med Chem Lett 16: 2076-80 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.059
BindingDB Entry DOI: 10.7270/Q28K78PW |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50182332
(2-(5-(4-(furan-2-yl)phenyl)-3-(trifluoromethyl)-1H...)Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(cc1)-c1ccco1)C(F)(F)F Show InChI InChI=1S/C20H14F3N3O3S/c1-30(27,28)15-8-9-19(24-12-15)26-16(11-18(25-26)20(21,22)23)13-4-6-14(7-5-13)17-3-2-10-29-17/h2-12H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Veterinary Medicine Research and Development Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of COX2 in canine whole blood |
Bioorg Med Chem Lett 16: 2076-80 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.059
BindingDB Entry DOI: 10.7270/Q28K78PW |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184126
(4'-trifluoromethyl-biphenyl-2-carboxylic acid (4-{...)Show SMILES CCCCN(C)C(=O)[C@@H](NC(=O)c1ccc(NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)cc1OC)c1ccccc1 Show InChI InChI=1S/C35H34F3N3O4/c1-4-5-21-41(2)34(44)31(24-11-7-6-8-12-24)40-33(43)29-20-19-26(22-30(29)45-3)39-32(42)28-14-10-9-13-27(28)23-15-17-25(18-16-23)35(36,37)38/h6-20,22,31H,4-5,21H2,1-3H3,(H,39,42)(H,40,43)/t31-/m0/s1 | PDB
Reactome pathway
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184154
(CHEMBL206965 | N-((S)-benzylcarbamoyl-phenyl-methy...)Show SMILES FC(F)(F)c1ccc(cc1)-c1ccccc1C(=O)Nc1ccc(cn1)C(=O)N[C@H](C(=O)NCc1ccccc1)c1ccccc1 Show InChI InChI=1S/C35H27F3N4O3/c36-35(37,38)27-18-15-24(16-19-27)28-13-7-8-14-29(28)33(44)41-30-20-17-26(22-39-30)32(43)42-31(25-11-5-2-6-12-25)34(45)40-21-23-9-3-1-4-10-23/h1-20,22,31H,21H2,(H,40,45)(H,42,43)(H,39,41,44)/t31-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 22.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184146
(4'-trifluoromethyl-biphenyl-2-carboxylic acid (4-{...)Show SMILES COc1cc(NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)ccc1C(=O)N[C@H](C(=O)N(C)Cc1ccccc1)c1ccccc1 Show InChI InChI=1S/C38H32F3N3O4/c1-44(24-25-11-5-3-6-12-25)37(47)34(27-13-7-4-8-14-27)43-36(46)32-22-21-29(23-33(32)48-2)42-35(45)31-16-10-9-15-30(31)26-17-19-28(20-18-26)38(39,40)41/h3-23,34H,24H2,1-2H3,(H,42,45)(H,43,46)/t34-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 23.1 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184119
(1-(4'-trifluoromethyl-biphenyl-2-carbonyl)-piperid...)Show SMILES CCCCN(C)C(=O)[C@@H](NC(=O)C1CCN(CC1)C(=O)c1ccccc1-c1ccc(cc1)C(F)(F)F)c1ccccc1 Show InChI InChI=1S/C33H36F3N3O3/c1-3-4-20-38(2)32(42)29(24-10-6-5-7-11-24)37-30(40)25-18-21-39(22-19-25)31(41)28-13-9-8-12-27(28)23-14-16-26(17-15-23)33(34,35)36/h5-17,25,29H,3-4,18-22H2,1-2H3,(H,37,40)/t29-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 23.6 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
Microsomal triglyceride transfer protein large subunit
(Homo sapiens (Human)) | BDBM50184167
(1-(4'-trifluoromethyl-biphenyl-2-carbonyl)-2,3-dih...)Show SMILES CN(Cc1ccccc1)C(=O)[C@@H](NC(=O)c1ccc2N(CCc2c1)C(=O)c1ccccc1-c1ccc(cc1)C(F)(F)F)c1ccccc1 Show InChI InChI=1S/C39H32F3N3O3/c1-44(25-26-10-4-2-5-11-26)38(48)35(28-12-6-3-7-13-28)43-36(46)30-18-21-34-29(24-30)22-23-45(34)37(47)33-15-9-8-14-32(33)27-16-19-31(20-17-27)39(40,41)42/h2-21,24,35H,22-23,25H2,1H3,(H,43,46)/t35-/m0/s1 | PDB
Reactome pathway
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| n/a | n/a | 26.6 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MTP in canine liver microsomes |
Bioorg Med Chem Lett 16: 3039-42 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.058
BindingDB Entry DOI: 10.7270/Q2D21X68 |
More data for this
Ligand-Target Pair | |
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