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TargetLong-chain fatty acid transport protein 4
LigandBDBM50186009
Substrate/Competitorn/a
Meas. Tech.ChEMBL_372182 (CHEMBL870441)
IC50 600±n/a nM
Citation Blackburn, CGuan, BBrown, JCullis, CCondon, SMJenkins, TJPeluso, SYe, YGimeno, REPunreddy, SSun, YWu, HHubbard, BKaushik, VTummino, PSanchetti, PYu Sun, DDaniels, TTozzo, EBalani, SKRaman, P Identification and characterization of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones as inhibitors of the fatty acid transporter FATP4. Bioorg Med Chem Lett16:3504-9 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Long-chain fatty acid transport protein 4
Name:Long-chain fatty acid transport protein 4
Synonyms:ACSVL4 | FATP4 | Fatty acid transport protein 4 | S27A4_HUMAN | SLC27A4
Type:PROTEIN
Mol. Mass.:72079.54
Organism:Homo sapiens (Human)
Description:ChEMBL_372182
Residue:643
Sequence:
MLLGASLVGVLLFSKLVLKLPWTQVGFSLLFLYLGSGGWRFIRVFIKTIRRDIFGGLVLL
KVKAKVRQCLQERRTVPILFASTVRRHPDKTALIFEGTDTHWTFRQLDEYSSSVANFLQA
RGLASGDVAAIFMENRNEFVGLWLGMAKLGVEAALINTNLRRDALLHCLTTSRARALVFG
SEMASAICEVHASLDPSLSLFCSGSWEPGAVPPSTEHLDPLLKDAPKHLPSCPDKGFTDK
LFYIYTSGTTGLPKAAIVVHSRYYRMAALVYYGFRMRPNDIVYDCLPLYHSAGNIVGIGQ
CLLHGMTVVIRKKFSASRFWDDCIKYNCTIVQYIGELCRYLLNQPPREAENQHQVRMALG
NGLRQSIWTNFSSRFHIPQVAEFYGATECNCSLGNFDSQVGACGFNSRILSFVYPIRLVR
VNEDTMELIRGPDGVCIPCQPGEPGQLVGRIIQKDPLRRFDGYLNQGANNKKIAKDVFKK
GDQAYLTGDVLVMDELGYLYFRDRTGDTFRWKGENVSTTEVEGTLSRLLDMADVAVYGVE
VPGTEGRAGMAAVASPTGNCDLERFAQVLEKELPLYARPIFLRLLPELHKTGTYKFQKTE
LRKEGFDPAIVKDPLFYLDAQKGRYVPLDQEAYSRIQAGEEKL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50186009
n/a
NameBDBM50186009
Synonyms:(S)-cyclopentyl 6-methyl-2-oxo-4-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate | CHEMBL212149
TypeSmall organic molecule
Emp. Form.C18H19F3N2O3
Mol. Mass.368.3503
SMILESCC1=NC(=O)N[C@H](C1C(=O)OC1CCCC1)c1ccc(cc1)C(F)(F)F |t:1|
Structure
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