Ki Summary

Reaction Details

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Target

Long-chain fatty acid transport protein 4

Ligand

BDBM50186037

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_372182 (CHEMBL870441)

IC50

8000±n/a nM

Citation

Blackburn, C; Guan, B; Brown, J; Cullis, C; Condon, SM; Jenkins, TJ; Peluso, S; Ye, Y; Gimeno, RE; Punreddy, S; Sun, Y; Wu, H; Hubbard, B; Kaushik, V; Tummino, P; Sanchetti, P; Yu Sun, D; Daniels, T; Tozzo, E; Balani, SK; Raman, P Identification and characterization of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones as inhibitors of the fatty acid transporter FATP4. Bioorg Med Chem Lett16:3504-9 (2006) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Long-chain fatty acid transport protein 4

Name:

Long-chain fatty acid transport protein 4

Synonyms:

ACSVL4 | FATP4 | Fatty acid transport protein 4 | S27A4_HUMAN | SLC27A4

Type:

PROTEIN

Mol. Mass.:

72079.54

Organism:

Homo sapiens (Human)

Description:

ChEMBL_372182

Residue:

643

Sequence:

MLLGASLVGVLLFSKLVLKLPWTQVGFSLLFLYLGSGGWRFIRVFIKTIRRDIFGGLVLL
KVKAKVRQCLQERRTVPILFASTVRRHPDKTALIFEGTDTHWTFRQLDEYSSSVANFLQA
RGLASGDVAAIFMENRNEFVGLWLGMAKLGVEAALINTNLRRDALLHCLTTSRARALVFG
SEMASAICEVHASLDPSLSLFCSGSWEPGAVPPSTEHLDPLLKDAPKHLPSCPDKGFTDK
LFYIYTSGTTGLPKAAIVVHSRYYRMAALVYYGFRMRPNDIVYDCLPLYHSAGNIVGIGQ
CLLHGMTVVIRKKFSASRFWDDCIKYNCTIVQYIGELCRYLLNQPPREAENQHQVRMALG
NGLRQSIWTNFSSRFHIPQVAEFYGATECNCSLGNFDSQVGACGFNSRILSFVYPIRLVR
VNEDTMELIRGPDGVCIPCQPGEPGQLVGRIIQKDPLRRFDGYLNQGANNKKIAKDVFKK
GDQAYLTGDVLVMDELGYLYFRDRTGDTFRWKGENVSTTEVEGTLSRLLDMADVAVYGVE
VPGTEGRAGMAAVASPTGNCDLERFAQVLEKELPLYARPIFLRLLPELHKTGTYKFQKTE
LRKEGFDPAIVKDPLFYLDAQKGRYVPLDQEAYSRIQAGEEKL

BDBM50186037

n/a

Name

BDBM50186037

Synonyms:

CHEMBL210290 | cyclopentyl 6-methyl-4-(4-(methylthio)phenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Type

Small organic molecule

Emp. Form.

C18H22N2O3S

Mol. Mass.

346.444

SMILES

CSc1ccc(cc1)C1NC(=O)N=C(C)C1C(=O)OC1CCCC1 |t:13|

Structure