| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 6 |
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| Ligand | BDBM50605024 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2249884 (CHEMBL5164094) |
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| Ki | 73±n/a nM |
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| Citation |  Grychowska, K; Olejarz-Maciej, A; Blicharz, K; Pietru?, W; Karcz, T; Kurczab, R; Koczurkiewicz, P; Doroz-P?onka, A; Latacz, G; Keeri, AR; Piska, K; Sata?a, G; P?giel, J; Tryba?a, W; Jastrz?bska-Wi?sek, M; Bojarski, AJ; Lamaty, F; Partyka, A; Walczak, M; Krawczyk, M; Malikowska-Racia, N; Popik, P; Zajdel, P Overcoming undesirable hERG affinity by incorporating fluorine atoms: A case of MAO-B inhibitors derived from 1 H-pyrrolo-[3,2-c]quinolines. Eur J Med Chem236:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 6 |
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| Name: | 5-hydroxytryptamine receptor 6 |
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| Synonyms: | 5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 46968.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P50406 |
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| Residue: | 440 |
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| Sequence: | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
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| BDBM50605024 |
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| n/a |
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| Name | BDBM50605024 |
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| Synonyms: | CHEMBL5183690 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H18ClN3O3S |
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| Mol. Mass. | 427.904 |
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| SMILES | Clc1cccc(c1)S(=O)(=O)n1ccc2c(N[C@H]3CCOC3)nc3ccccc3c12 |r| |
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| Structure | 
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