| Reaction Details |
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 | Report a problem with these data |
| Target | E3 ubiquitin-protein ligase Mdm2 |
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| Ligand | BDBM50605107 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2250443 (CHEMBL5164653) |
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| Ki | 5.9±n/a nM |
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| Citation |  Zhang, S; Yan, Z; Li, Y; Gong, Y; Lyu, X; Lou, J; Zhang, D; Meng, X; Zhao, Y Structure-Based Discovery of MDM2/4 Dual Inhibitors that Exert Antitumor Activities against MDM4-Overexpressing Cancer Cells. J Med Chem65:6207-6230 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| E3 ubiquitin-protein ligase Mdm2 |
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| Name: | E3 ubiquitin-protein ligase Mdm2 |
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| Synonyms: | Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein |
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| Type: | Oncoprotein |
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| Mol. Mass.: | 55196.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q00987 |
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| Residue: | 491 |
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| Sequence: | MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDS
VSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLA
DYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVP
DCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQ
DKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQ
PIQMIVLTYFP
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| BDBM50605107 |
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| n/a |
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| Name | BDBM50605107 |
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| Synonyms: | CHEMBL5194658 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H39Cl2F2N3O4 |
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| Mol. Mass. | 662.594 |
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| SMILES | CCCNC[C@@]1([C@H](CC(C)(C)C)N[C@H]([C@@H]1c1cccc(Cl)c1F)C(=O)Nc1ccc(cc1OC)C(O)=O)c1ccc(Cl)cc1F |r| |
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| Structure | 
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