| Reaction Details |
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 | Report a problem with these data |
| Target | Integrase |
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| Ligand | BDBM50187187 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_383533 (CHEMBL867996) |
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| IC50 | 255±n/a nM |
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| Citation |  Fardis, M; Jin, H; Jabri, S; Cai, RZ; Mish, M; Tsiang, M; Kim, CU Effect of substitution on novel tricyclic HIV-1 integrase inhibitors. Bioorg Med Chem Lett16:4031-5 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Integrase |
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| Name: | Integrase |
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| Synonyms: | Human immunodeficiency virus type 1 integrase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 32231.48 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_90865 |
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| Residue: | 288 |
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| Sequence: | FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
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| BDBM50187187 |
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| n/a |
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| Name | BDBM50187187 |
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| Synonyms: | 7-(4-fluorobenzyl)-9-hydroxy-8-oxo-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-5-yl dimethylsulfamate | CHEMBL214371 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H18FN3O5S |
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| Mol. Mass. | 431.437 |
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| SMILES | CN(C)S(=O)(=O)Oc1c2CN(Cc3ccc(F)cc3)C(=O)c2c(O)c2ncccc12 |
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| Structure | 
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