| Reaction Details |
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 | Report a problem with these data |
| Target | Peroxisome proliferator-activated receptor alpha |
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| Ligand | BDBM50188254 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_380765 (CHEMBL867358) |
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| EC50 | 340±n/a nM |
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| Citation |  Epple, R; Russo, R; Azimioara, M; Cow, C; Xie, Y; Wang, X; Wityak, J; Karanewsky, D; Gerken, A; Iskandar, M; Saez, E; Martin Seidel, H; Tian, SS 3,4,5-Trisubstituted isoxazoles as novel PPARdelta agonists: Part 1. Bioorg Med Chem Lett16:4376-80 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peroxisome proliferator-activated receptor alpha |
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| Name: | Peroxisome proliferator-activated receptor alpha |
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| Synonyms: | NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha) |
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| Type: | Enzyme |
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| Mol. Mass.: | 52222.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07869 |
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| Residue: | 468 |
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| Sequence: | MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC
PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV
IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI
FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
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| BDBM50188254 |
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| n/a |
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| Name | BDBM50188254 |
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| Synonyms: | 2-(3-chloro-4-(5-methyl-4-((2-(2-nitro-4-(trifluoromethyl)phenoxy)ethyl)carbamoyl)isoxazol-3-yl)phenyl)acetic acid | CHEMBL214295 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H17ClF3N3O7 |
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| Mol. Mass. | 527.834 |
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| SMILES | Cc1onc(c1C(=O)NCCOc1ccc(cc1[N+]([O-])=O)C(F)(F)F)-c1ccc(CC(O)=O)cc1Cl |
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| Structure | 
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