Reaction Details |
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Target | Sodium- and chloride-dependent glycine transporter 1 |
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Ligand | BDBM50188363 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_378748 (CHEMBL871493) |
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EC50 | 24±n/a nM |
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Citation | Alberati, D; Hainzl, D; Jolidon, S; Krafft, EA; Kurt, A; Maier, A; Pinard, E; Thomas, AW; Zimmerli, D Discovery of 4-substituted-8-(2-hydroxy-2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of highly selective GlyT1 inhibitors with improved metabolic stability. Bioorg Med Chem Lett16:4311-5 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium- and chloride-dependent glycine transporter 1 |
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Name: | Sodium- and chloride-dependent glycine transporter 1 |
Synonyms: | GlyT-1 | GlyT1 | Glycine Transporters (GlyT1c) | Glycine transporter 1 | SC6A9_HUMAN | SLC6A9 | Sodium- and chloride-dependent glycine transporter 1 | Sodium- and chloride-dependent glycine transporter 1 (GlyT1) | Sodium- and chloride-dependent glycine transporter 1 (GlyT1c) | Sodium-and chloride-dependent glycine transporter 1 (GlyT-1c) | Solute carrier family 6 member 9 |
Type: | Enzyme |
Mol. Mass.: | 78270.54 |
Organism: | Homo sapiens (Human) |
Description: | P48067 |
Residue: | 706 |
Sequence: | MSGGDTRAAIARPRMAAAHGPVAPSSPEQVTLLPVQRSFFLPPFSGATPSTSLAESVLKV
WHGAYNSGLLPQLMAQHSLAMAQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGL
GNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKG
VGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTN
GSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLV
VFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKV
WGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGF
MANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETL
VTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVIS
CIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITY
NHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLE
HRTGRYAPTIAPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI
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BDBM50188363 |
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n/a |
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Name | BDBM50188363 |
Synonyms: | 8-[2-(4-fluoro-phenyl)-2-hydroxy-cyclohexyl]-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one | CHEMBL385360 |
Type | Small organic molecule |
Emp. Form. | C25H30FN3O2 |
Mol. Mass. | 423.523 |
SMILES | OC1(CCCCC1N1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccc(F)cc1 |
Structure |
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