| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein ENL |
|---|
| Ligand | BDBM50606146 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2253823 (CHEMBL5168033) |
|---|
| Ki | 184±n/a nM |
|---|
| Citation |  Yuan, Y; Du, L; Tan, R; Yu, Y; Jiang, J; Yao, A; Luo, J; Tang, R; Xiao, Y; Sun, H Design, Synthesis, and Biological Evaluations of DOT1L Peptide Mimetics Targeting the Protein-Protein Interactions between DOT1L and MLL-AF9/MLL-ENL. J Med Chem65:7770-7785 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein ENL |
|---|
| Name: | Protein ENL |
|---|
| Synonyms: | ENL | ENL_HUMAN | LTG19 | MLLT1 | Protein ENL | YEATS domain-containing protein 1 | YEATS1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 62068.50 |
|---|
| Organism: | Homo sapiens |
|---|
| Description: | ChEMBL_118046 |
|---|
| Residue: | 559 |
|---|
| Sequence: | MDNQCTVQVRLELGHRAQLRKKPTTEGFTHDWMVFVRGPEQCDIQHFVEKVVFWLHDSFP
KPRRVCKEPPYKVEESGYAGFIMPIEVHFKNKEEPRKVCFTYDLFLNLEGNPPVNHLRCE
KLTFNNPTTEFRYKLLRAGGVMVMPEGADTVSRPSPDYPMLPTIPLSAFSDPKKTKPSHG
SKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPK
EEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPATADSPKPSAKKQ
KKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESN
SEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSS
SGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPPPNSKVSGRRSPESCS
KPEKILKKGTYDKAYTDELVELHRRLMALRERNVLQQIVNLIEETGHFNVTNTTFDFDLF
SLDETTVRKLQSCLEAVAT
|
|
|
|---|
| BDBM50606146 |
|---|
| n/a |
|---|
| Name | BDBM50606146 |
|---|
| Synonyms: | CHEMBL5206253 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C44H63N9O6 |
|---|
| Mol. Mass. | 814.0277 |
|---|
| SMILES | CC(C)C[C@H](NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CN)C(=O)N[C@@H](CC1CCCC1)C(=O)N[C@@H](C)c1nc2cccc(-c3ccccc3)c2[nH]1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
