| Reaction Details |
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 | Report a problem with these data |
| Target | Protein ENL |
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| Ligand | BDBM50606138 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2253823 (CHEMBL5168033) |
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| Ki | 231±n/a nM |
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| Citation |  Yuan, Y; Du, L; Tan, R; Yu, Y; Jiang, J; Yao, A; Luo, J; Tang, R; Xiao, Y; Sun, H Design, Synthesis, and Biological Evaluations of DOT1L Peptide Mimetics Targeting the Protein-Protein Interactions between DOT1L and MLL-AF9/MLL-ENL. J Med Chem65:7770-7785 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein ENL |
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| Name: | Protein ENL |
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| Synonyms: | ENL | ENL_HUMAN | LTG19 | MLLT1 | Protein ENL | YEATS domain-containing protein 1 | YEATS1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 62068.50 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_118046 |
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| Residue: | 559 |
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| Sequence: | MDNQCTVQVRLELGHRAQLRKKPTTEGFTHDWMVFVRGPEQCDIQHFVEKVVFWLHDSFP
KPRRVCKEPPYKVEESGYAGFIMPIEVHFKNKEEPRKVCFTYDLFLNLEGNPPVNHLRCE
KLTFNNPTTEFRYKLLRAGGVMVMPEGADTVSRPSPDYPMLPTIPLSAFSDPKKTKPSHG
SKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPK
EEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPATADSPKPSAKKQ
KKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESN
SEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSS
SGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPPPNSKVSGRRSPESCS
KPEKILKKGTYDKAYTDELVELHRRLMALRERNVLQQIVNLIEETGHFNVTNTTFDFDLF
SLDETTVRKLQSCLEAVAT
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| BDBM50606138 |
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| n/a |
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| Name | BDBM50606138 |
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| Synonyms: | CHEMBL5207031 |
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| Type | Small organic molecule |
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| Emp. Form. | C44H56N8O5 |
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| Mol. Mass. | 776.966 |
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| SMILES | CNC[C@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)c1ccccc1)C(C)C)C(=O)N[C@@H](CC1CCCC1)C(=O)N[C@@H](C)c1nc2cccc(-c3ccccc3)c2[nH]1 |r| |
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| Structure | 
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