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TargetMelanocyte-stimulating hormone receptor
LigandBDBM50189016
Substrate/Competitorn/a
Meas. Tech.ChEMBL_395992 (CHEMBL910337)
Ki 21703±n/a nM
Citation Tian, XMishra, RKSwitzer, AGHu, XEKim, NMazur, AWEbetino, FHWos, JACrossdoersen, DPinney, BBFarmer, JASheldon, RJ Design and synthesis of potent and selective 1,3,4-trisubstituted-2-oxopiperazine based melanocortin-4 receptor agonists. Bioorg Med Chem Lett16:4668-73 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Melanocyte-stimulating hormone receptor
Name:Melanocyte-stimulating hormone receptor
Synonyms:MC1-R | MC1R | MSH-R | MSHR | MSHR_HUMAN | Melanocortin MC1 | Melanocortin receptor (M1 and M4) | Melanocortin receptor 1 (MC-1) | Melanocortin receptor 1 (MC1-R) | Melanocortin receptor 1 (MC1R)
Type:Enzyme
Mol. Mass.:34717.23
Organism:Homo sapiens (Human)
Description:Q01726
Residue:317
Sequence:
MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVV
ATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVI
DVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFI
AYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGA
VTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAF
HSQELRRTLKEVLTCSW
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  Blast E-value cutoff:
BDBM50189016
n/a
NameBDBM50189016
Synonyms:1-(2-((S)-1-((R)-2-amino-3-(4-fluorophenyl)propanoyl)-4-((S)-1-(methylamino)-3-(naphthalen-2-yl)-1-oxopropan-2-yl)-3-oxopiperazin-2-yl)ethyl)urea | CHEMBL212855
TypeSmall organic molecule
Emp. Form.C30H35FN6O4
Mol. Mass.562.6351
SMILESCNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCNC(N)=O)C1=O)C(=O)[C@H](N)Cc1ccc(F)cc1
Structure
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