Reaction Details |
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Target | Deoxyuridine 5'-triphosphate nucleotidohydrolase |
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Ligand | BDBM50190530 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_373621 (CHEMBL869761) |
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Ki | 1600±n/a nM |
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Citation | Nguyen, C; Ruda, GF; Schipani, A; Kasinathan, G; Leal, I; Musso-Buendia, A; Kaiser, M; Brun, R; Ruiz-Pérez, LM; Sahlberg, BL; Johansson, NG; Gonzalez-Pacanowska, D; Gilbert, IH Acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase. J Med Chem49:4183-95 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Deoxyuridine 5'-triphosphate nucleotidohydrolase |
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Name: | Deoxyuridine 5'-triphosphate nucleotidohydrolase |
Synonyms: | dUTP pyrophosphatase |
Type: | Protein |
Mol. Mass.: | 19574.43 |
Organism: | Plasmodium falciparum |
Description: | Q8II92 |
Residue: | 173 |
Sequence: | MHLKIVCLSDEVREMYKNHKTHHEGDSGLDLFIVKDEVLKPKSTTFVKLGIKAIALQYKS
NYYYKCEKSENKKKDDDKSNIVNTSFLLFPRSSISKTPLRLANSIGLIDAGYRGEIIAAL
DNTSDQEYHIKKNDKLVQLVSFTGEPLSFELVEELDETSRGEGGFGSTSNNKY
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BDBM50190530 |
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n/a |
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Name | BDBM50190530 |
Synonyms: | 1-(4-trityloxybutyl)uracil | CHEMBL211067 |
Type | Small organic molecule |
Emp. Form. | C27H26N2O3 |
Mol. Mass. | 426.5069 |
SMILES | O=c1ccn(CCCCOC(c2ccccc2)(c2ccccc2)c2ccccc2)c(=O)[nH]1 |
Structure |
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