Reaction Details |
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Target | Substance-P receptor |
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Ligand | BDBM50190815 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_405761 (CHEMBL869873) |
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IC50 | 2.1±n/a nM |
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Citation | Finke, PE; Meurer, LC; Levorse, DA; Mills, SG; Maccoss, M; Sadowski, S; Cascieri, MA; Tsao, KL; Chicchi, GG; Metzger, JM; Macintyre, DE Cyclopentane-based human NK1 antagonists. Part 1: discovery and initial SAR. Bioorg Med Chem Lett16:4497-503 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Substance-P receptor |
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Name: | Substance-P receptor |
Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46254.43 |
Organism: | Homo sapiens (Human) |
Description: | P25103 |
Residue: | 407 |
Sequence: | MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
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BDBM50190815 |
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n/a |
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Name | BDBM50190815 |
Synonyms: | (+/-)-cis-2-((3-(3,5-bis(trifluoromethyl)benzyloxy)-2-phenylcyclopentyl)(methyl)amino)acetamide | CHEMBL379707 |
Type | Small organic molecule |
Emp. Form. | C23H24F6N2O2 |
Mol. Mass. | 474.4393 |
SMILES | CN(CC(N)=O)[C@H]1CC[C@H](OCc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c1ccccc1 |
Structure |
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