| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 1A2 |
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| Ligand | BDBM50191163 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_397084 (CHEMBL864261) |
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| IC50 | 21000±n/a nM |
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| Citation |  McKeown, SC; Hall, A; Giblin, GM; Lorthioir, O; Blunt, R; Lewell, XQ; Wilson, RJ; Brown, SH; Chowdhury, A; Coleman, T; Watson, SP; Chessell, IP; Pipe, A; Clayton, N; Goldsmith, P Identification of novel pyrazole acid antagonists for the EP1 receptor. Bioorg Med Chem Lett16:4767-71 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 1A2 |
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| Name: | Cytochrome P450 1A2 |
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| Synonyms: | CP1A2_HUMAN | CYP1A2 | CYPIA2 | Cholesterol 25-hydroxylase | Cytochrome P(3)450 | Cytochrome P450 1A | Cytochrome P450 1A2 (CYP1A2) | Cytochrome P450 4 | Cytochrome P450-P3 |
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| Type: | Enzyme |
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| Mol. Mass.: | 58423.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P05177 |
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| Residue: | 516 |
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| Sequence: | MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKN
PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG
QSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELM
AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFP
ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGN
LIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLS
DRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPEL
WEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLE
FSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN
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| BDBM50191163 |
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| n/a |
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| Name | BDBM50191163 |
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| Synonyms: | 1-(2-(benzyloxy)-5-bromobenzyl)-5-methyl-1H-pyrazole-3-carboxylic acid | CHEMBL213221 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H17BrN2O3 |
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| Mol. Mass. | 401.254 |
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| SMILES | Cc1cc(nn1Cc1cc(Br)ccc1OCc1ccccc1)C(O)=O |
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| Structure | 
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