Reaction Details |
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Target | Imipenem-hydrolyzing beta-lactamase |
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Ligand | BDBM50191387 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_365443 (CHEMBL869110) |
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IC50 | 22±n/a nM |
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Citation | Venkatesan, AM; Agarwal, A; Abe, T; Ushirogochi, H; Yamamura, I; Ado, M; Tsuyoshi, T; Dos Santos, O; Gu, Y; Sum, FW; Li, Z; Francisco, G; Lin, YI; Petersen, PJ; Yang, Y; Kumagai, T; Weiss, WJ; Shlaes, DM; Knox, JR; Mansour, TS Structure-activity relationship of 6-methylidene penems bearing 6,5 bicyclic heterocycles as broad-spectrum beta-lactamase inhibitors: evidence for 1,4-thiazepine intermediates with C7 R stereochemistry by computational methods. J Med Chem49:4623-37 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Imipenem-hydrolyzing beta-lactamase |
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Name: | Imipenem-hydrolyzing beta-lactamase |
Synonyms: | BLAN_ENTCL | nmcA |
Type: | PROTEIN |
Mol. Mass.: | 32077.29 |
Organism: | Enterobacter cloacae |
Description: | ChEMBL_365443 |
Residue: | 292 |
Sequence: | MSLNVKQSRIAILFSSCLISISFFSQANTKGIDEIKNLETDFNGRIGVYALDTGSGKSFS
YRANERFPLCSSFKGFLAAAVLKGSQDNRLNLNQIVNYNTRSLEFHSPITTKYKDNGMSL
GDMAAAALQYSDNGATNIILERYIGGPEGMTKFMRSIGDEDFRLDRWELDLNTAIPGDER
DTSTPAAVAKSLKTLALGNILSEHEKETYQTWLKGNTTGAARIRASVPSDWVVGDKTGSC
GAYGTANDYAVVWPKNRAPLIISVYTTKNEKEAKHEDKVIAEASRIAIDNLK
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BDBM50191387 |
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n/a |
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Name | BDBM50191387 |
Synonyms: | (5R),(6Z)-6-(7-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-2-ylmethylene)-7-oxo-4-thia-1-aza-bicyclo-[3.2.0]hept-2-ene-2-carboxylic acid sodium salt | CHEMBL212478 |
Type | Small organic molecule |
Emp. Form. | C14H13N4O3S |
Mol. Mass. | 317.344 |
SMILES | CN1CCn2cc(\C=C3/[C@H]4SC=C(N4C3=O)C([O-])=O)nc2C1 |c:11| |
Structure |
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