| Reaction Details |
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 | Report a problem with these data |
| Target | Monoglyceride lipase |
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| Ligand | BDBM50411264 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2268931 |
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| IC50 | 18±n/a nM |
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| Citation |  Rong, J; Mori, W; Xia, X; Schafroth, MA; Zhao, C; Van, RS; Yamasaki, T; Chen, J; Xiao, Z; Haider, A; Ogasawara, D; Hiraishi, A; Shao, T; Zhang, Y; Chen, Z; Pang, F; Hu, K; Xie, L; Fujinaga, M; Kumata, K; Gou, Y; Fang, Y; Gu, S; Wei, H; Bao, L; Xu, H; Collier, TL; Shao, Y; Carson, RE; Cravatt, BF; Wang, L; Zhang, MR; Liang, SH Novel Reversible-Binding PET Ligands for Imaging Monoacylglycerol Lipase Based on the Piperazinyl Azetidine Scaffold. J Med Chem64:14283-14298 (2021) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Monoglyceride lipase |
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| Name: | Monoglyceride lipase |
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| Synonyms: | HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN |
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| Type: | Hydrolase |
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| Mol. Mass.: | 33264.56 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human recombinant MGL (Cayman Chemical, cat# 10008354). |
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| Residue: | 303 |
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| Sequence: | MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEE
LARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLG
HSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPID
SSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADR
LCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTA
SPP
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| BDBM50411264 |
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| n/a |
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| Name | BDBM50411264 |
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| Synonyms: | CHEMBL5290125 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H25FN6O2S |
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| Mol. Mass. | 504.579 |
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| SMILES | Cc1cc(cc(F)n1)-n1ccc2cc(ccc12)C(=O)N1CC(C1)N1CCN(CC1)C(=O)c1nccs1 |
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| Structure | 
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