| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 2D6 |
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| Ligand | BDBM50106737 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2278502 |
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| IC50 | >10000±n/a nM |
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| Citation |  Yuan, Y; Yao, H; Zhou, M; Ma, X; Zhou, Y; Xu, J; Niu, M; Yin, J; Zheng, L; Xu, S Identification of a Novel Potent CYP4Z1 Inhibitor Attenuating the Stemness of Breast Cancer Cells through Lead Optimization. J Med Chem65:15749-15769 (2022) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 2D6 |
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| Name: | Cytochrome P450 2D6 |
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| Synonyms: | CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1 |
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| Type: | Protein |
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| Mol. Mass.: | 55774.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10635 |
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| Residue: | 497 |
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| Sequence: | MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
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| BDBM50106737 |
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| n/a |
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| Name | BDBM50106737 |
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| Synonyms: | CHEMBL267865 | N-(4-Butyl-2-methyl-phenyl)-N'-hydroxy-formamidine | N-(4-butyl-2-methylphenyl)-N''-hydroxyimidoformamide | N-(4-butyl-2-methylphenyl)-N'-hydroxyimidoformamide |
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| Type | Small organic molecule |
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| Emp. Form. | C12H18N2O |
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| Mol. Mass. | 206.2841 |
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| SMILES | CCCCc1ccc(NC=NO)c(C)c1 |w:10.10| |
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| Structure | 
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