Reaction Details |
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Target | CTP synthase 1 |
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Ligand | BDBM50609669 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2278988 |
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IC50 | 440±n/a nM |
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Citation | Novak, A; Laughton, D; Lane, R; Blackham, E; Thomas, J; Chatzopoulou, E; Wrigglesworth, J; Quddus, A; Ahmed, S; Cousin, D; Duffy, L; Dubois, N; Unitt, J; Orban, K; Browne, E; Ward, M; Mycock, D; Ieva, M; Bland, N; George, P; Bourne, T; Asnagli, H; Birch, L; Jones, G Discovery and Optimization of Potent and Orally Available CTP Synthetase Inhibitors for Use in Treatment of Diseases Driven by Aberrant Immune Cell Proliferation. J Med Chem65:16640-16650 (2022) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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CTP synthase 1 |
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Name: | CTP synthase 1 |
Synonyms: | 6.3.4.2 | CTP synthase 1 | CTP synthetase 1 | Ctps | Ctps1 | UTP--ammonia ligase 1 |
Type: | PROTEIN |
Mol. Mass.: | 66682.19 |
Organism: | Mus musculus |
Description: | ChEMBL_120967 |
Residue: | 591 |
Sequence: | MKYILVTGGVISGIGKGVIASSVGTILKSCGLHVTSIKIDPYINIDAGTFSPYEHGEVFV
LDDGGEVDLDLGNYERFLDIRLTKDNNLTTGKIYQYVINKERKGDYLGKTVQVVPHITDA
IQEWVMRQALIPVDEDGLEPQVCVIELGGTVGDIESMPFIEAFRQFQFKVKRENFCNIHV
SLVPQPSSTGEQKTKPTQNSVRELRGLGLSPDLVVCRCSNPLDTSVKEKISMFCHVEPEQ
VICVHDVSSIYRVPLLLEEQGVVDYFLRRLDLPIERQSRKMLMKWKEMADRYDRLLETCS
IALVGKYTKFSDSYASVIKALEHSALAINHKLEIKYIDSTDLEPSTLQEEPVRYHEAWQK
LCSAHGVLVPGGFGVRGTEGKIQAIAWARKQKKPFLGVCLGMQLAVVEFSRNVLGWQDAN
STEFDPKTSHPVVIDMPEHNPGQMGGTMRLGKRRTLFQTKNSVMRKLYGDTDYLEERHRH
RFEVNPVLKKCLEEQGLKFVGQDVEGERMEIVELEDHPFFVGVQYHPEFLSRPIKPSPPY
FGLLLASVGRLPHYLQKGCRLSPRDTYSDRSGSSSPDSEITELKFPSISQD
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BDBM50609669 |
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n/a |
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Name | BDBM50609669 |
Synonyms: | CHEMBL5288393 |
Type | Small organic molecule |
Emp. Form. | C19H25N3O4S2 |
Mol. Mass. | 423.549 |
SMILES | CCCOc1ccc(NC(=O)C(C)(C)c2csc(NS(=O)(=O)C3CC3)n2)cc1 |
Structure |
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