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Compile Data Set for Download or QSAR

Found 1411 hits with Last Name = 'lane' and Initial = 'r'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50530705
PNG
(CHEMBL4451384)
Show SMILES [H][C@]12CC[C@]([H])(CC(O)(C1)c1ccc(Cl)cc1)N2CCCC(=O)c1ccc(F)cc1 |r,TLB:18:17:2.3:6.7.9|
Show InChI InChI=1S/C23H25ClFNO2/c24-18-7-5-17(6-8-18)23(28)14-20-11-12-21(15-23)26(20)13-1-2-22(27)16-3-9-19(25)10-4-16/h3-10,20-21,28H,1-2,11-15H2/t20-,21+,23?
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 0.0525n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assay

J Med Chem 62: 9488-9520 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00864
BindingDB Entry DOI: 10.7270/Q2NP27WQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50530705
PNG
(CHEMBL4451384)
Show SMILES [H][C@]12CC[C@]([H])(CC(O)(C1)c1ccc(Cl)cc1)N2CCCC(=O)c1ccc(F)cc1 |r,TLB:18:17:2.3:6.7.9|
Show InChI InChI=1S/C23H25ClFNO2/c24-18-7-5-17(6-8-18)23(28)14-20-11-12-21(15-23)26(20)13-1-2-22(27)16-3-9-19(25)10-4-16/h3-10,20-21,28H,1-2,11-15H2/t20-,21+,23?
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 0.0525n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assay

J Med Chem 62: 9488-9520 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00864
BindingDB Entry DOI: 10.7270/Q2NP27WQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50530680
PNG
(CHEMBL4570273)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1cccc(Cl)c1Cl
Show InChI InChI=1S/C21H22Cl2FNO2/c22-18-4-1-3-17(20(18)23)21(27)10-13-25(14-11-21)12-2-5-19(26)15-6-8-16(24)9-7-15/h1,3-4,6-9,27H,2,5,10-14H2
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 0.120n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assay

J Med Chem 62: 9488-9520 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00864
BindingDB Entry DOI: 10.7270/Q2NP27WQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50530680
PNG
(CHEMBL4570273)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1cccc(Cl)c1Cl
Show InChI InChI=1S/C21H22Cl2FNO2/c22-18-4-1-3-17(20(18)23)21(27)10-13-25(14-11-21)12-2-5-19(26)15-6-8-16(24)9-7-15/h1,3-4,6-9,27H,2,5,10-14H2
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 0.120n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assay

J Med Chem 62: 9488-9520 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00864
BindingDB Entry DOI: 10.7270/Q2NP27WQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50530700
PNG
(CHEMBL4544491)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H22Cl2FNO2/c22-18-8-5-16(14-19(18)23)21(27)9-12-25(13-10-21)11-1-2-20(26)15-3-6-17(24)7-4-15/h3-8,14,27H,1-2,9-13H2
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 0.155n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assay

J Med Chem 62: 9488-9520 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00864
BindingDB Entry DOI: 10.7270/Q2NP27WQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50530700
PNG
(CHEMBL4544491)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H22Cl2FNO2/c22-18-8-5-16(14-19(18)23)21(27)9-12-25(13-10-21)11-1-2-20(26)15-3-6-17(24)7-4-15/h3-8,14,27H,1-2,9-13H2
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 0.155n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assay

J Med Chem 62: 9488-9520 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00864
BindingDB Entry DOI: 10.7270/Q2NP27WQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50530676
PNG
(CHEMBL4528835)
Show SMILES Fc1ccc(cc1)C(=O)CCCN1CCC2(CC2C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H23ClFNO/c23-19-7-5-17(6-8-19)22-11-13-25(15-18(22)14-22)12-1-2-21(26)16-3-9-20(24)10-4-16/h3-10,18H,1-2,11-15H2
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 0.158n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assay

J Med Chem 62: 9488-9520 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00864
BindingDB Entry DOI: 10.7270/Q2NP27WQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50530676
PNG
(CHEMBL4528835)
Show SMILES Fc1ccc(cc1)C(=O)CCCN1CCC2(CC2C1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H23ClFNO/c23-19-7-5-17(6-8-19)22-11-13-25(15-18(22)14-22)12-1-2-21(26)16-3-9-20(24)10-4-16/h3-10,18H,1-2,11-15H2
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 0.158n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assay

J Med Chem 62: 9488-9520 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00864
BindingDB Entry DOI: 10.7270/Q2NP27WQ
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))		BDBM50017698
PNG
(4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N,N...)
Show SMILES CN(C)C(=O)C(CCN1CCC(O)(CC1)c1ccc(Cl)cc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H33ClN2O2/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32-20-17-28(34,18-21-32)23-13-15-26(30)16-14-23/h3-16,34H,17-22H2,1-2H3
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 0.268n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of [3H]DAMGO from human mu opioid receptor expressed in HEK293 cell membrane incubated for 60 mins by radioligand binding assay

Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00611
BindingDB Entry DOI: 10.7270/Q2N301V5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50530683
PNG
(CHEMBL4436610)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C22H23F4NO2/c23-19-9-3-16(4-10-19)20(28)2-1-13-27-14-11-21(29,12-15-27)17-5-7-18(8-6-17)22(24,25)26/h3-10,29H,1-2,11-15H2
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 0.324n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assay

J Med Chem 62: 9488-9520 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00864
BindingDB Entry DOI: 10.7270/Q2NP27WQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50530683
PNG
(CHEMBL4436610)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C22H23F4NO2/c23-19-9-3-16(4-10-19)20(28)2-1-13-27-14-11-21(29,12-15-27)17-5-7-18(8-6-17)22(24,25)26/h3-10,29H,1-2,11-15H2
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 0.324n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assay

J Med Chem 62: 9488-9520 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00864
BindingDB Entry DOI: 10.7270/Q2NP27WQ
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))		BDBM50585129
PNG
(CHEMBL5077645)
Show SMILES [H][C@@]12CCC[C@@](CCN1C\C=C\c1ccccc1)([C@@H]2O)c1cccc(O)c1 |r,THB:9:8:4.3.2:18|
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 0.377n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of [3H]DAMGO from human mu opioid receptor expressed in HEK293 cell membrane incubated for 60 mins by radioligand binding assay

Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00611
BindingDB Entry DOI: 10.7270/Q2N301V5
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50302220
PNG
(7-((1-((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-...)
Show SMILES Fc1ccc2[nH]c3CCC(CN4CCC(COc5cccc6[nH]c(=O)oc56)CC4)Cc3c2c1
Show InChI InChI=1S/C26H28FN3O3/c27-18-5-7-22-20(13-18)19-12-17(4-6-21(19)28-22)14-30-10-8-16(9-11-30)15-32-24-3-1-2-23-25(24)33-26(31)29-23/h1-3,5,7,13,16-17,28H,4,6,8-12,14-15H2,(H,29,31)
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 0.400n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assay

Bioorg Med Chem Lett 19: 5552-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.050
BindingDB Entry DOI: 10.7270/Q2Z89DCC
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50530682
PNG
(CHEMBL4436241)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C21H22Cl2FNO2/c22-17-12-16(13-18(23)14-17)21(27)7-10-25(11-8-21)9-1-2-20(26)15-3-5-19(24)6-4-15/h3-6,12-14,27H,1-2,7-11H2
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 0.447n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assay

J Med Chem 62: 9488-9520 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00864
BindingDB Entry DOI: 10.7270/Q2NP27WQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50530682
PNG
(CHEMBL4436241)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C21H22Cl2FNO2/c22-17-12-16(13-18(23)14-17)21(27)7-10-25(11-8-21)9-1-2-20(26)15-3-5-19(24)6-4-15/h3-6,12-14,27H,1-2,7-11H2
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 0.447n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assay

J Med Chem 62: 9488-9520 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00864
BindingDB Entry DOI: 10.7270/Q2NP27WQ
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50267216
PNG
(CHEMBL4077536)
Show SMILES Clc1cccc(N2CCN(C[C@@H]3C[C@H]3CNC(=O)c3cc4ccccc4[nH]3)CC2)c1Cl |r|
Show InChI InChI=1S/C24H26Cl2N4O/c25-19-5-3-7-22(23(19)26)30-10-8-29(9-11-30)15-18-12-17(18)14-27-24(31)21-13-16-4-1-2-6-20(16)28-21/h1-7,13,17-18,28H,8-12,14-15H2,(H,27,31)/t17-,18-/m0/s1
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 0.450n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylspiperone from human D3 receptor expressed in HEK293 cell membranes after 1 hr by liquid scintillation counting analysis

J Med Chem 60: 1478-1494 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01688
BindingDB Entry DOI: 10.7270/Q2NV9MRV
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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 0.468n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assay

J Med Chem 62: 9488-9520 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00864
BindingDB Entry DOI: 10.7270/Q2NP27WQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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 0.468n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assay

J Med Chem 62: 9488-9520 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00864
BindingDB Entry DOI: 10.7270/Q2NP27WQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50021819
PNG
(CHEMBL3298828)
Show SMILES COc1nc2sc(C(=O)NCCCCCCN3CCC(CC3)c3ccc(Cl)cc3)c(N)c2c(C)c1Cl
Show InChI InChI=1S/C27H34Cl2N4O2S/c1-17-21-23(30)24(36-27(21)32-26(35-2)22(17)29)25(34)31-13-5-3-4-6-14-33-15-11-19(12-16-33)18-7-9-20(28)10-8-18/h7-10,19H,3-6,11-16,30H2,1-2H3,(H,31,34)
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 0.600n/an/an/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human D2L receptor expressed in FlpIn CHO cell membrane after 3 hrs by liquid scintillation counting analysis

J Med Chem 57: 4924-39 (2014)


Article DOI: 10.1021/jm500457x
BindingDB Entry DOI: 10.7270/Q29Z96FS
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))		BDBM50585128
PNG
(CHEMBL5080654)
Show SMILES [H][C@@]12CCC[C@@](CCN1CCc1ccccc1)(\C2=C\C(=O)OCC)c1cccc(O)c1 |r,THB:9:8:4.3.2:17|
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 0.633n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of [3H]DAMGO from human mu opioid receptor expressed in HEK293 cell membrane incubated for 60 mins by radioligand binding assay

Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00611
BindingDB Entry DOI: 10.7270/Q2N301V5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM81486
PNG
(CAS_1050-79-9 | MOPERONE | NSC_4249)
Show SMILES Cc1ccc(cc1)C1(O)CCN(CCCC(=O)c2ccc(F)cc2)CC1
Show InChI InChI=1S/C22H26FNO2/c1-17-4-8-19(9-5-17)22(26)12-15-24(16-13-22)14-2-3-21(25)18-6-10-20(23)11-7-18/h4-11,26H,2-3,12-16H2,1H3
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 0.724n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assay

J Med Chem 62: 9488-9520 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00864
BindingDB Entry DOI: 10.7270/Q2NP27WQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM81486
PNG
(CAS_1050-79-9 | MOPERONE | NSC_4249)
Show SMILES Cc1ccc(cc1)C1(O)CCN(CCCC(=O)c2ccc(F)cc2)CC1
Show InChI InChI=1S/C22H26FNO2/c1-17-4-8-19(9-5-17)22(26)12-15-24(16-13-22)14-2-3-21(25)18-6-10-20(23)11-7-18/h4-11,26H,2-3,12-16H2,1H3
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 0.724n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assay

J Med Chem 62: 9488-9520 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00864
BindingDB Entry DOI: 10.7270/Q2NP27WQ
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))		BDBM50585107
PNG
(CHEMBL5085974)
Show SMILES CN(C)C(=O)C(CCN1CCN(CC1)c1cccc(Cl)c1Cl)(c1ccccc1)c1ccccc1
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 0.832n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of [3H]DAMGO from human mu opioid receptor expressed in HEK293 cell membrane incubated for 60 mins by radioligand binding assay

Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00611
BindingDB Entry DOI: 10.7270/Q2N301V5
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))		BDBM50585112
PNG
(CHEMBL5088070)
Show SMILES CCc1cccc(N2CCN(CCC(C(=O)N(C)C)(c3ccccc3)c3ccccc3)CC2)c1Cl
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 0.842n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of [3H]DAMGO from human mu opioid receptor expressed in HEK293 cell membrane incubated for 60 mins by radioligand binding assay

Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00611
BindingDB Entry DOI: 10.7270/Q2N301V5
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50267224
PNG
(CHEMBL4089939)
Show SMILES O=C(NCC[C@@H]1C[C@H]1CN1CCc2ccc(cc2C1)C#N)c1cc2ccccc2[nH]1 |r|
Show InChI InChI=1S/C25H26N4O/c26-14-17-5-6-18-8-10-29(15-21(18)11-17)16-22-12-19(22)7-9-27-25(30)24-13-20-3-1-2-4-23(20)28-24/h1-6,11,13,19,22,28H,7-10,12,15-16H2,(H,27,30)/t19-,22+/m1/s1
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 0.890n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylspiperone from human D3 receptor expressed in HEK293 cell membranes after 1 hr by liquid scintillation counting analysis

J Med Chem 60: 1478-1494 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01688
BindingDB Entry DOI: 10.7270/Q2NV9MRV
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50530681
PNG
(CHEMBL4529368)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1cc(Cl)ccc1Cl
Show InChI InChI=1S/C21H22Cl2FNO2/c22-16-5-8-19(23)18(14-16)21(27)9-12-25(13-10-21)11-1-2-20(26)15-3-6-17(24)7-4-15/h3-8,14,27H,1-2,9-13H2
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 1n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assay

J Med Chem 62: 9488-9520 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00864
BindingDB Entry DOI: 10.7270/Q2NP27WQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50530709
PNG
(CHEMBL4455788)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1cccc(Cl)c1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-4-1-3-17(15-18)21(26)10-13-24(14-11-21)12-2-5-20(25)16-6-8-19(23)9-7-16/h1,3-4,6-9,15,26H,2,5,10-14H2
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 1n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assay

J Med Chem 62: 9488-9520 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00864
BindingDB Entry DOI: 10.7270/Q2NP27WQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50530709
PNG
(CHEMBL4455788)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1cccc(Cl)c1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-4-1-3-17(15-18)21(26)10-13-24(14-11-21)12-2-5-20(25)16-6-8-19(23)9-7-16/h1,3-4,6-9,15,26H,2,5,10-14H2
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 1n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assay

J Med Chem 62: 9488-9520 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00864
BindingDB Entry DOI: 10.7270/Q2NP27WQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50530681
PNG
(CHEMBL4529368)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1cc(Cl)ccc1Cl
Show InChI InChI=1S/C21H22Cl2FNO2/c22-16-5-8-19(23)18(14-16)21(27)9-12-25(13-10-21)11-1-2-20(26)15-3-6-17(24)7-4-15/h3-8,14,27H,1-2,9-13H2
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 1n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assay

J Med Chem 62: 9488-9520 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00864
BindingDB Entry DOI: 10.7270/Q2NP27WQ
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50302225
PNG
((1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl...)
Show SMILES CN(C)CCC[C@]1(OCc2cc(ccc12)C#N)c1ccc(F)cc1 |r|
Show InChI InChI=1S/C20H21FN2O/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20/h4-9,12H,3,10-11,14H2,1-2H3/t20-/m0/s1
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 1n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assay

Bioorg Med Chem Lett 19: 5552-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.050
BindingDB Entry DOI: 10.7270/Q2Z89DCC
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50362868
PNG
(CHEMBL1940404)
Show SMILES OC1(CCN(CCCOc2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H23ClFNO2/c21-17-4-2-16(3-5-17)20(24)10-13-23(14-11-20)12-1-15-25-19-8-6-18(22)7-9-19/h2-9,24H,1,10-15H2
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 1.10n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assay

J Med Chem 62: 9488-9520 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00864
BindingDB Entry DOI: 10.7270/Q2NP27WQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50362868
PNG
(CHEMBL1940404)
Show SMILES OC1(CCN(CCCOc2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H23ClFNO2/c21-17-4-2-16(3-5-17)20(24)10-13-23(14-11-20)12-1-15-25-19-8-6-18(22)7-9-19/h2-9,24H,1,10-15H2
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 1.10n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assay

J Med Chem 62: 9488-9520 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00864
BindingDB Entry DOI: 10.7270/Q2NP27WQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50380565
PNG
(CHEMBL2016628)
Show SMILES Clc1ccc2Nc3ccccc3C(=Nc2c1)N1CCN(CCCNC(=O)CCCCCCCCC(=O)NCCCN2CCN(CC2)C2=Nc3cc(Cl)ccc3Nc3ccccc23)CC1 |c:13,t:50|
Show InChI InChI=1S/C50H62Cl2N10O2/c51-37-19-21-43-45(35-37)57-49(39-13-7-9-15-41(39)55-43)61-31-27-59(28-32-61)25-11-23-53-47(63)17-5-3-1-2-4-6-18-48(64)54-24-12-26-60-29-33-62(34-30-60)50-40-14-8-10-16-42(40)56-44-22-20-38(52)36-46(44)58-50/h7-10,13-16,19-22,35-36,55-56H,1-6,11-12,17-18,23-34H2,(H,53,63)(H,54,64)
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 1.23n/an/an/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from human dopamine D2L receptor expressed in CHO FlpIn cell membrane measured after 60 mins by topcount scintillation...

J Med Chem 55: 1622-34 (2012)


Article DOI: 10.1021/jm201420s
BindingDB Entry DOI: 10.7270/Q2GB2524
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50380565
PNG
(CHEMBL2016628)
Show SMILES Clc1ccc2Nc3ccccc3C(=Nc2c1)N1CCN(CCCNC(=O)CCCCCCCCC(=O)NCCCN2CCN(CC2)C2=Nc3cc(Cl)ccc3Nc3ccccc23)CC1 |c:13,t:50|
Show InChI InChI=1S/C50H62Cl2N10O2/c51-37-19-21-43-45(35-37)57-49(39-13-7-9-15-41(39)55-43)61-31-27-59(28-32-61)25-11-23-53-47(63)17-5-3-1-2-4-6-18-48(64)54-24-12-26-60-29-33-62(34-30-60)50-40-14-8-10-16-42(40)56-44-22-20-38(52)36-46(44)58-50/h7-10,13-16,19-22,35-36,55-56H,1-6,11-12,17-18,23-34H2,(H,53,63)(H,54,64)
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 1.35n/an/an/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from human dopamine D2L receptor expressed in CHO FlpIn cell membrane measured after 60 mins by topcount scintillation...

J Med Chem 55: 1622-34 (2012)


Article DOI: 10.1021/jm201420s
BindingDB Entry DOI: 10.7270/Q2GB2524
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50380567
PNG
(CHEMBL2016627)
Show SMILES Clc1ccc2Nc3ccccc3C(=Nc2c1)N1CCN(CCCNC(=O)CCCCCCC(=O)NCCCN2CCN(CC2)C2=Nc3cc(Cl)ccc3Nc3ccccc23)CC1 |c:13,t:48|
Show InChI InChI=1S/C48H58Cl2N10O2/c49-35-17-19-41-43(33-35)55-47(37-11-5-7-13-39(37)53-41)59-29-25-57(26-30-59)23-9-21-51-45(61)15-3-1-2-4-16-46(62)52-22-10-24-58-27-31-60(32-28-58)48-38-12-6-8-14-40(38)54-42-20-18-36(50)34-44(42)56-48/h5-8,11-14,17-20,33-34,53-54H,1-4,9-10,15-16,21-32H2,(H,51,61)(H,52,62)
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 1.35n/an/an/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from human dopamine D2L receptor expressed in CHO FlpIn cell membrane measured after 60 mins by topcount scintillation...

J Med Chem 55: 1622-34 (2012)


Article DOI: 10.1021/jm201420s
BindingDB Entry DOI: 10.7270/Q2GB2524
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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 1.40n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of [3H]-N-methylspiperone from human dopamine D4 receptor expressed in HEK293 cell membranes incubated for 60 mins by microbeta scintill...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00611
BindingDB Entry DOI: 10.7270/Q2N301V5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50380567
PNG
(CHEMBL2016627)
Show SMILES Clc1ccc2Nc3ccccc3C(=Nc2c1)N1CCN(CCCNC(=O)CCCCCCC(=O)NCCCN2CCN(CC2)C2=Nc3cc(Cl)ccc3Nc3ccccc23)CC1 |c:13,t:48|
Show InChI InChI=1S/C48H58Cl2N10O2/c49-35-17-19-41-43(33-35)55-47(37-11-5-7-13-39(37)53-41)59-29-25-57(26-30-59)23-9-21-51-45(61)15-3-1-2-4-16-46(62)52-22-10-24-58-27-31-60(32-28-58)48-38-12-6-8-14-40(38)54-42-20-18-36(50)34-44(42)56-48/h5-8,11-14,17-20,33-34,53-54H,1-4,9-10,15-16,21-32H2,(H,51,61)(H,52,62)
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 1.41n/an/an/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from human dopamine D2L receptor expressed in CHO FlpIn cell membrane measured after 60 mins by topcount scintillation...

J Med Chem 55: 1622-34 (2012)


Article DOI: 10.1021/jm201420s
BindingDB Entry DOI: 10.7270/Q2GB2524
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50530698
PNG
(CHEMBL4472382)
Show SMILES OC1(CCN(CC[C@H]2C[C@@H]2c2ccc(F)cc2)CC1)c1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C22H25ClFNO/c23-19-5-3-18(4-6-19)22(26)10-13-25(14-11-22)12-9-17-15-21(17)16-1-7-20(24)8-2-16/h1-8,17,21,26H,9-15H2/t17-,21+/m0/s1
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 1.5n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assay

J Med Chem 62: 9488-9520 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00864
BindingDB Entry DOI: 10.7270/Q2NP27WQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50530673
PNG
(CHEMBL4453290)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1c(Cl)cccc1Cl
Show InChI InChI=1S/C21H22Cl2FNO2/c22-17-3-1-4-18(23)20(17)21(27)10-13-25(14-11-21)12-2-5-19(26)15-6-8-16(24)9-7-15/h1,3-4,6-9,27H,2,5,10-14H2
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 1.5n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assay

J Med Chem 62: 9488-9520 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00864
BindingDB Entry DOI: 10.7270/Q2NP27WQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50530673
PNG
(CHEMBL4453290)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1c(Cl)cccc1Cl
Show InChI InChI=1S/C21H22Cl2FNO2/c22-17-3-1-4-18(23)20(17)21(27)10-13-25(14-11-21)12-2-5-19(26)15-6-8-16(24)9-7-15/h1,3-4,6-9,27H,2,5,10-14H2
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 1.5n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assay

J Med Chem 62: 9488-9520 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00864
BindingDB Entry DOI: 10.7270/Q2NP27WQ
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50267217
PNG
(CHEMBL4083903)
Show SMILES Clc1cccc(N2CCN(C[C@@H]3C[C@H]3CNC(=O)c3ccnc4ccccc34)CC2)c1Cl |r|
Show InChI InChI=1S/C25H26Cl2N4O/c26-21-5-3-7-23(24(21)27)31-12-10-30(11-13-31)16-18-14-17(18)15-29-25(32)20-8-9-28-22-6-2-1-4-19(20)22/h1-9,17-18H,10-16H2,(H,29,32)/t17-,18-/m0/s1
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 1.5n/an/an/an/an/an/an/an/a



National Institute on Drug Abuse

Curated by ChEMBL


Assay Description
Displacement of [3H]N-methylspiperone from human D3 receptor expressed in HEK293 cell membranes after 1 hr by liquid scintillation counting analysis

J Med Chem 60: 1478-1494 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01688
BindingDB Entry DOI: 10.7270/Q2NV9MRV
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50530698
PNG
(CHEMBL4472382)
Show SMILES OC1(CCN(CC[C@H]2C[C@@H]2c2ccc(F)cc2)CC1)c1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C22H25ClFNO/c23-19-5-3-18(4-6-19)22(26)10-13-25(14-11-22)12-9-17-15-21(17)16-1-7-20(24)8-2-16/h1-8,17,21,26H,9-15H2/t17-,21+/m0/s1
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 1.5n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assay

J Med Chem 62: 9488-9520 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00864
BindingDB Entry DOI: 10.7270/Q2NP27WQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50233623
PNG
(CHEMBL4104013)
Show SMILES O=C1COc2ccccc2N1CCCN1CCN(CC1)c1cccc2[nH]c(=O)oc12
Show InChI InChI=1S/C22H24N4O4/c27-20-15-29-19-8-2-1-6-17(19)26(20)10-4-9-24-11-13-25(14-12-24)18-7-3-5-16-21(18)30-22(28)23-16/h1-3,5-8H,4,9-15H2,(H,23,28)
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 1.70n/an/an/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Displacement of [3H]-raclopride from human dopamine D2L receptor expressed in F1pIn CHO cells after 60 mins by scintillation counting analysis

J Med Chem 58: 1550-5 (2015)


Article DOI: 10.1021/jm5013243
BindingDB Entry DOI: 10.7270/Q2F76FTG
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50474701
PNG
(CHEMBL147830)
Show SMILES Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO/c22-19-7-3-16(4-8-19)17-11-14-24(15-12-17)13-1-2-21(25)18-5-9-20(23)10-6-18/h3-10,17H,1-2,11-15H2
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 1.70n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assay

J Med Chem 62: 9488-9520 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00864
BindingDB Entry DOI: 10.7270/Q2NP27WQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50233623
PNG
(CHEMBL4104013)
Show SMILES O=C1COc2ccccc2N1CCCN1CCN(CC1)c1cccc2[nH]c(=O)oc12
Show InChI InChI=1S/C22H24N4O4/c27-20-15-29-19-8-2-1-6-17(19)26(20)10-4-9-24-11-13-25(14-12-24)18-7-3-5-16-21(18)30-22(28)23-16/h1-3,5-8H,4,9-15H2,(H,23,28)
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 1.70n/an/an/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Displacement of [3H]-raclopride from human dopamine D2L receptor expressed in F1pIn CHO cells after 60 mins by scintillation counting analysis

J Med Chem 58: 1550-5 (2015)


Article DOI: 10.1021/jm5013243
BindingDB Entry DOI: 10.7270/Q2F76FTG
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50474701
PNG
(CHEMBL147830)
Show SMILES Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO/c22-19-7-3-16(4-8-19)17-11-14-24(15-12-17)13-1-2-21(25)18-5-9-20(23)10-6-18/h3-10,17H,1-2,11-15H2
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 1.70n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assay

J Med Chem 62: 9488-9520 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00864
BindingDB Entry DOI: 10.7270/Q2NP27WQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50027218
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccccc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H24ClNO2/c22-19-10-8-18(9-11-19)21(25)12-15-23(16-13-21)14-4-7-20(24)17-5-2-1-3-6-17/h1-3,5-6,8-11,25H,4,7,12-16H2
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 1.80n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assay

J Med Chem 62: 9488-9520 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00864
BindingDB Entry DOI: 10.7270/Q2NP27WQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50027218
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccccc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H24ClNO2/c22-19-10-8-18(9-11-19)21(25)12-15-23(16-13-21)14-4-7-20(24)17-5-2-1-3-6-17/h1-3,5-6,8-11,25H,4,7,12-16H2
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 1.80n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assay

J Med Chem 62: 9488-9520 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00864
BindingDB Entry DOI: 10.7270/Q2NP27WQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50530693
PNG
(CHEMBL422334)
Show SMILES COC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H25ClFNO2/c1-27-22(18-6-8-19(23)9-7-18)12-15-25(16-13-22)14-2-3-21(26)17-4-10-20(24)11-5-17/h4-11H,2-3,12-16H2,1H3
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 1.90n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assay

J Med Chem 62: 9488-9520 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00864
BindingDB Entry DOI: 10.7270/Q2NP27WQ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50530693
PNG
(CHEMBL422334)
Show SMILES COC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H25ClFNO2/c1-27-22(18-6-8-19(23)9-7-18)12-15-25(16-13-22)14-2-3-21(26)17-4-10-20(24)11-5-17/h4-11H,2-3,12-16H2,1H3
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 1.90n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Displacement of PPHT-red from SNAP-tagged human D2LR expressed in CHOK1 cell membranes by TR-FRET assay

J Med Chem 62: 9488-9520 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00864
BindingDB Entry DOI: 10.7270/Q2NP27WQ
More data for this
Ligand-Target Pair
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