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TargetG-protein coupled bile acid receptor 1
LigandBDBM50613573
Substrate/Competitorn/a
Meas. Tech.ChEMBL_2292574
EC50 47±n/a nM
Citation Kuhn, BGuba, WHert, JBanner, DBissantz, CCeccarelli, SHaap, WKörner, MKuglstatter, ALerner, CMattei, PNeidhart, WPinard, ERudolph, MGSchulz-Gasch, TWoltering, TStahl, M A Real-World Perspective on Molecular Design. J Med Chem59:4087-102 (2016) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
G-protein coupled bile acid receptor 1
Name:G-protein coupled bile acid receptor 1
Synonyms:BG37 | GPBAR1 | GPBAR_HUMAN | M-BAR | TGR5 | hBG37 | hGPCR19
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:35260.02
Organism:Homo sapiens (Human)
Description:CHO cells transiently transfected with hTGR5.
Residue:330
Sequence:
MTPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLA
GLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQP
PGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGA
AAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPY
VATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWRAAAQRCLQ
GLWGRASRDSPGPSIAYHPSSQSSVDLDLN
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BDBM50613573
n/a
NameBDBM50613573
Synonyms:CHEMBL5286406
TypeSmall organic molecule
Emp. Form.C24H20Cl2N2O4
Mol. Mass.471.333
SMILESOC(=O)CCc1cc(Cl)c(Oc2ncccc2C(=O)N2CCCc3ccccc23)cc1Cl
Structure
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