| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Hormone-sensitive lipase |
|---|
| Ligand | BDBM50613577 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2292575 |
|---|
| IC50 | 30±n/a nM |
|---|
| Citation |  Kuhn, B; Guba, W; Hert, J; Banner, D; Bissantz, C; Ceccarelli, S; Haap, W; Körner, M; Kuglstatter, A; Lerner, C; Mattei, P; Neidhart, W; Pinard, E; Rudolph, MG; Schulz-Gasch, T; Woltering, T; Stahl, M A Real-World Perspective on Molecular Design. J Med Chem59:4087-102 (2016) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Hormone-sensitive lipase |
|---|
| Name: | Hormone-sensitive lipase |
|---|
| Synonyms: | HSL | Hormone sensitive lipase | Hormone-sensitive lipase (HSL) | LIPE | LIPS_HUMAN |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 116599.07 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q05469 |
|---|
| Residue: | 1076 |
|---|
| Sequence: | MEPGSKSVSRSDWQPEPHQRPITPLEPGPEKTPIAQPESKTLQGSNTQQKPASNQRPLTQ
QETPAQHDAESQKEPRAQQKSASQEEFLAPQKPAPQQSPYIQRVLLTQQEAASQQGPGLG
KESITQQEPALRQRHVAQPGPGPGEPPPAQQEAESTPAAQAKPGAKREPSAPTESTSQET
PEQSDKQTTPVQGAKSKQGSLTELGFLTKLQELSIQRSALEWKALSEWVTDSESESDVGS
SSDTDSPATMGGMVAQGVKLGFKGKSGYKVMSGYSGTSPHEKTSARNHRHYQDTASRLIH
NMDLRTMTQSLVTLAEDNIAFFSSQGPGETAQRLSGVFAGVREQALGLEPALGRLLGVAH
LFDLDPETPANGYRSLVHTARCCLAHLLHKSRYVASNRRSIFFRTSHNLAELEAYLAALT
QLRALVYYAQRLLVTNRPGVLFFEGDEGLTADFLREYVTLHKGCFYGRCLGFQFTPAIRP
FLQTISIGLVSFGEHYKRNETGLSVAASSLFTSGRFAIDPELRGAEFERITQNLDVHFWK
AFWNITEMEVLSSLANMASATVRVSRLLSLPPEAFEMPLTADPTLTVTISPPLAHTGPGP
VLVRLISYDLREGQDSEELSSLIKSNGQRSLELWPRPQQAPRSRSLIVHFHGGGFVAQTS
RSHEPYLKSWAQELGAPIISIDYSLAPEAPFPRALEECFFAYCWAIKHCALLGSTGERIC
LAGDSAGGNLCFTVALRAAAYGVRVPDGIMAAYPATMLQPAASPSRLLSLMDPLLPLSVL
SKCVSAYAGAKTEDHSNSDQKALGMMGLVRRDTALLLRDFRLGASSWLNSFLELSGRKSQ
KMSEPIAEPMRRSVSEAALAQPQGPLGTDSLKNLTLRDLSLRGNSETSSDTPEMSLSAET
LSPSTPSDVNFLLPPEDAGEEAEAKNELSPMDRGLGVRAAFPEGFHPRRSSQGATQMPLY
SSPIVKNPFMSPLLAPDSMLKSLPPVHIVACALDPMLDDSVMLARRLRNLGQPVTLRVVE
DLPHGFLTLAALCRETRQAAELCVERIRLVLTPPAGAGPSGETGAAGVDGGCGGRH
|
|
|
|---|
| BDBM50613577 |
|---|
| n/a |
|---|
| Name | BDBM50613577 |
|---|
| Synonyms: | CHEMBL5291436 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H20ClF3N2O4S |
|---|
| Mol. Mass. | 488.908 |
|---|
| SMILES | FC(F)(F)Oc1ccc(cc1)N1CCC2(CCN(CC2)S(=O)(=O)c2ccccc2Cl)C1=O |
|---|
| Structure | 
|
|---|
Search and Browse
