Ki Summary

Reaction Details

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Target

Hormone-sensitive lipase

Ligand

BDBM50613578

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2292575

IC50

20±n/a nM

Citation

Kuhn, B; Guba, W; Hert, J; Banner, D; Bissantz, C; Ceccarelli, S; Haap, W; K�rner, M; Kuglstatter, A; Lerner, C; Mattei, P; Neidhart, W; Pinard, E; Rudolph, MG; Schulz-Gasch, T; Woltering, T; Stahl, M A Real-World Perspective on Molecular Design. J Med Chem59:4087-102 (2016) [PubMed]

More Info.:

Get all data from this article, Assay Method

Hormone-sensitive lipase

Name:

Hormone-sensitive lipase

Synonyms:

HSL | Hormone sensitive lipase | Hormone-sensitive lipase (HSL) | LIPE | LIPS_HUMAN

Type:

Protein

Mol. Mass.:

116599.07

Organism:

Homo sapiens (Human)

Description:

Q05469

Residue:

1076

Sequence:

MEPGSKSVSRSDWQPEPHQRPITPLEPGPEKTPIAQPESKTLQGSNTQQKPASNQRPLTQ
QETPAQHDAESQKEPRAQQKSASQEEFLAPQKPAPQQSPYIQRVLLTQQEAASQQGPGLG
KESITQQEPALRQRHVAQPGPGPGEPPPAQQEAESTPAAQAKPGAKREPSAPTESTSQET
PEQSDKQTTPVQGAKSKQGSLTELGFLTKLQELSIQRSALEWKALSEWVTDSESESDVGS
SSDTDSPATMGGMVAQGVKLGFKGKSGYKVMSGYSGTSPHEKTSARNHRHYQDTASRLIH
NMDLRTMTQSLVTLAEDNIAFFSSQGPGETAQRLSGVFAGVREQALGLEPALGRLLGVAH
LFDLDPETPANGYRSLVHTARCCLAHLLHKSRYVASNRRSIFFRTSHNLAELEAYLAALT
QLRALVYYAQRLLVTNRPGVLFFEGDEGLTADFLREYVTLHKGCFYGRCLGFQFTPAIRP
FLQTISIGLVSFGEHYKRNETGLSVAASSLFTSGRFAIDPELRGAEFERITQNLDVHFWK
AFWNITEMEVLSSLANMASATVRVSRLLSLPPEAFEMPLTADPTLTVTISPPLAHTGPGP
VLVRLISYDLREGQDSEELSSLIKSNGQRSLELWPRPQQAPRSRSLIVHFHGGGFVAQTS
RSHEPYLKSWAQELGAPIISIDYSLAPEAPFPRALEECFFAYCWAIKHCALLGSTGERIC
LAGDSAGGNLCFTVALRAAAYGVRVPDGIMAAYPATMLQPAASPSRLLSLMDPLLPLSVL
SKCVSAYAGAKTEDHSNSDQKALGMMGLVRRDTALLLRDFRLGASSWLNSFLELSGRKSQ
KMSEPIAEPMRRSVSEAALAQPQGPLGTDSLKNLTLRDLSLRGNSETSSDTPEMSLSAET
LSPSTPSDVNFLLPPEDAGEEAEAKNELSPMDRGLGVRAAFPEGFHPRRSSQGATQMPLY
SSPIVKNPFMSPLLAPDSMLKSLPPVHIVACALDPMLDDSVMLARRLRNLGQPVTLRVVE
DLPHGFLTLAALCRETRQAAELCVERIRLVLTPPAGAGPSGETGAAGVDGGCGGRH

BDBM50613578

n/a

Name

BDBM50613578

Synonyms:

CHEMBL5280062

Type

Small organic molecule

Emp. Form.

C19H24F3NO3

Mol. Mass.

371.394

SMILES

CCC[C@]1(O)CC[C@]2(CCN(C2=O)c2ccc(OC(F)(F)F)cc2)CC1 |r,wD:3.3,7.11,(4.96,-3.1,;6.27,-3.91,;6.23,-5.45,;7.54,-6.25,;6.19,-6.99,;8.28,-7.61,;9.82,-7.66,;10.63,-6.36,;11.36,-5,;12.87,-5.29,;13.07,-6.81,;11.69,-7.47,;11.4,-8.99,;14.43,-7.55,;14.46,-9.08,;15.81,-9.82,;17.12,-9.01,;18.48,-9.75,;18.52,-11.29,;19.87,-12.02,;17.21,-12.09,;18.47,-12.82,;17.08,-7.47,;15.73,-6.74,;9.89,-4.99,;8.36,-4.94,)|

Structure