| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 1A |
|---|
| Ligand | BDBM50206350 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_442632 (CHEMBL892800) |
|---|
| Ki | 21±n/a nM |
|---|
| Citation |  Zajdel, P; Subra, G; Bojarski, AJ; Duszynska, B; Tatarczynska, E; Nikiforuk, A; Chojnacka-Wójcik, E; Pawlowski, M; Martinez, J Novel class of arylpiperazines containing N-acylated amino acids: their synthesis, 5-HT1A, 5-HT2A receptor affinity, and in vivo pharmacological evaluation. Bioorg Med Chem15:2907-19 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 5-hydroxytryptamine receptor 1A |
|---|
| Name: | 5-hydroxytryptamine receptor 1A |
|---|
| Synonyms: | 5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 46445.29 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | Binding assays were performed using rat hippocampal membranes. |
|---|
| Residue: | 422 |
|---|
| Sequence: | MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR
|
|
|
|---|
| BDBM50206350 |
|---|
| n/a |
|---|
| Name | BDBM50206350 |
|---|
| Synonyms: | CHEMBL390037 | N-((S)-1-{4-[4-(3-chlorophenyl)piperazin-1-yl]butyl}pyrrolidin-2,5-dion-3-yl)-2-(bicyclo[2.2.1]heptan-2-yl)acetamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H37ClN4O3 |
|---|
| Mol. Mass. | 501.061 |
|---|
| SMILES | Clc1cccc(c1)N1CCN(CCCCN2C(=O)C[C@H](NC(=O)CC3CC4CCC3C4)C2=O)CC1 |w:24.24,29.29,26.27,TEB:23:24:27.28:30| |
|---|
| Structure | 
|
|---|
Search and Browse
