| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor X |
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| Ligand | BDBM50209904 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_443802 (CHEMBL892965) |
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| IC50 | 13±n/a nM |
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| Citation |  Ishihara, T; Seki, N; Hirayama, F; Orita, M; Koshio, H; Taniuchi, Y; Sakai-Moritani, Y; Iwatsuki, Y; Kaku, S; Kawasaki, T; Matsumoto, Y; Tsukamoto, S Prodrug-based design, synthesis, and biological evaluation of N-benzenesulfonylpiperidine derivatives as novel, orally active factor Xa inhibitors. Bioorg Med Chem15:4175-92 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor X |
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| Name: | Coagulation factor X |
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| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
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| Type: | Enzyme |
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| Mol. Mass.: | 54726.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 488 |
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| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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| BDBM50209904 |
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| n/a |
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| Name | BDBM50209904 |
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| Synonyms: | CHEMBL244436 | [(({7-[amino(imino)methyl]-2-naphthyl}methyl){1-[(2,5-dimethoxyphenyl)sulfonyl]piperidin-4-yl}amino)sulfonyl]acetic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C27H32N4O8S2 |
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| Mol. Mass. | 604.695 |
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| SMILES | COc1ccc(OC)c(c1)S(=O)(=O)N1CCC(CC1)N(Cc1ccc2ccc(cc2c1)C(N)=N)S(=O)(=O)CC(O)=O |
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| Structure | 
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