Reaction Details |
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Target | Retinoic acid receptor RXR-alpha |
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Ligand | BDBM50218451 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_440654 (CHEMBL889748) |
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IC50 | 720±n/a nM |
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Citation | Sakaki, J; Kishida, M; Konishi, K; Gunji, H; Toyao, A; Matsumoto, Y; Kanazawa, T; Uchiyama, H; Fukaya, H; Mitani, H; Arai, Y; Kimura, M Synthesis and structure-activity relationship of novel RXR antagonists: orally active anti-diabetic and anti-obesity agents. Bioorg Med Chem Lett17:4804-7 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Retinoic acid receptor RXR-alpha |
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Name: | Retinoic acid receptor RXR-alpha |
Synonyms: | NR2B1 | Nuclear receptor subfamily 2 group B member 1 | Nuclear receptor subfamily 4 group A member 2 | Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha | RXRA | RXRA_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoid X receptor alpha | Retinoid receptor |
Type: | PROTEIN |
Mol. Mass.: | 50820.38 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1456363 |
Residue: | 462 |
Sequence: | MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPING
MGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVP
AHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLID
KRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAEL
AVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVIL
LRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM
QMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLL
RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
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BDBM50218451 |
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n/a |
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Name | BDBM50218451 |
Synonyms: | 4-[2-(4-methoxy-phenylsulfanyl)-5,7,7,10,10-pentamethyl-7,8,9,10-tetrahydro-5H-5,13-diaza-benzo[4,5]cyclohepta[1,2-b]naphthalen-12-yl]-benzoic acid | CHEMBL395563 |
Type | Small organic molecule |
Emp. Form. | C36H36N2O3S |
Mol. Mass. | 576.748 |
SMILES | COc1ccc(Sc2ccc3N(C)c4cc5c(cc4C(=Nc3c2)c2ccc(cc2)C(O)=O)C(C)(C)CCC5(C)C)cc1 |c:20| |
Structure |
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