| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Chk1 |
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| Ligand | BDBM50220066 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_446023 (CHEMBL895119) |
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| IC50 | 43±n/a nM |
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| Citation |  Conchon, E; Anizon, F; Aboab, B; Prudhomme, M Synthesis and biological activities of new checkpoint kinase 1 inhibitors structurally related to granulatimide. J Med Chem50:4669-80 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase Chk1 |
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| Name: | Serine/threonine-protein kinase Chk1 |
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| Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 54443.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_166295192 |
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| Residue: | 476 |
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| Sequence: | MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
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| BDBM50220066 |
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| n/a |
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| Name | BDBM50220066 |
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| Synonyms: | 6,7-dihydro-1H-cyclopenta[a]pyrrolo[3,4-c]carbazole-1,3,4-(2H,5H)-trione | CHEMBL395016 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H10N2O3 |
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| Mol. Mass. | 290.2729 |
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| SMILES | O=C1CCc2c1c1C(=O)NC(=O)c1c1c2[nH]c2ccccc12 |
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| Structure | 
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